Antiviral effects of antisense morpholino oligomers in murine coronavirus infection models

The recent emergence of novel pathogenic human and animal coronaviruses has highlighted the need for antiviral therapies that are effective against a spectrum of these viruses. We have used several strains of murine hepatitis virus (MHV) in cell culture and in vivo in mouse models to investigate the...

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Vydané v:	Journal of virology Ročník 81; číslo 11; s. 5637
Hlavní autori:	Burrer, Renaud, Neuman, Benjamin W, Ting, Joey P C, Stein, David A, Moulton, Hong M, Iversen, Patrick L, Kuhn, Peter, Buchmeier, Michael J
Médium:	Journal Article
Jazyk:	English
Vydavateľské údaje:	United States 01.06.2007
Predmet:	Animals Antiviral Agents - pharmacology Cercopithecus aethiops Coronavirus Infections - drug therapy Coronavirus Infections - virology Disease Models, Animal Male Mice Mice, Inbred C57BL Morpholines - pharmacology Murine hepatitis virus - drug effects Murine hepatitis virus - genetics Oligonucleotides, Antisense - pharmacology Vero Cells Viral Load
ISSN:	0022-538X
On-line prístup:	Zistit podrobnosti o prístupe
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