Antiviral effects of antisense morpholino oligomers in murine coronavirus infection models

The recent emergence of novel pathogenic human and animal coronaviruses has highlighted the need for antiviral therapies that are effective against a spectrum of these viruses. We have used several strains of murine hepatitis virus (MHV) in cell culture and in vivo in mouse models to investigate the...

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Bibliographic Details

Published in:	Journal of virology Vol. 81; no. 11; p. 5637
Main Authors:	Burrer, Renaud, Neuman, Benjamin W, Ting, Joey P C, Stein, David A, Moulton, Hong M, Iversen, Patrick L, Kuhn, Peter, Buchmeier, Michael J
Format:	Journal Article
Language:	English
Published:	United States 01.06.2007
Subjects:	Animals Antiviral Agents - pharmacology Cercopithecus aethiops Coronavirus Infections - drug therapy Coronavirus Infections - virology Disease Models, Animal Male Mice Mice, Inbred C57BL Morpholines - pharmacology Murine hepatitis virus - drug effects Murine hepatitis virus - genetics Oligonucleotides, Antisense - pharmacology Vero Cells Viral Load
ISSN:	0022-538X
Online Access:	Get more information
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