Neural Infection by Oropouche Virus in Adult Human Brain Slices Induces an Inflammatory and Toxic Response

Oropouche virus (OROV) is an emerging arbovirus in South and Central Americas with high spreading potential. OROV infection has been associated with neurological complications and OROV genomic RNA has been detected in cerebrospinal fluid from patients, suggesting its neuroinvasive potential. Motivat...

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Bibliographic Details
Published in:	Frontiers in neuroscience Vol. 15; p. 674576
Main Authors:	Almeida, Glaucia M., Souza, Juliano P., Mendes, Niele D., Pontelli, Marjorie C., Pinheiro, Nathalia R., Nogueira, Giovanna O., Cardoso, Ricardo S., Paiva, Isadora M., Ferrari, Gustavo D., Veras, Flávio P., Cunha, Fernando Q., Horta-Junior, Jose A. C., Alberici, Luciane C., Cunha, Thiago M., Podolsky-Gondim, Guilherme G., Neder, Luciano, Arruda, Eurico, Sebollela, Adriano
Format:	Journal Article
Language:	English
Published:	Lausanne Frontiers Research Foundation 23.11.2021 Frontiers Media S.A
Subjects:	Animal models arboviruses Astrocytes Brain Brain architecture Brain slice preparation Case reports Cell viability Central nervous system Cerebrospinal fluid Chronic infection Diplopia Encephalitis Epidemics Ethanol histocultures Infections Inflammation Invasiveness Microglia neuroinfection neuroinflammation Neurological complications Neuropathogenesis Neuroscience Neurosciences neurotropic virus Severe acute respiratory syndrome coronavirus 2 Tumor necrosis factor-α viral encephalitis West Nile virus Zika virus
ISSN:	1662-453X, 1662-4548, 1662-453X
Online Access:	Get full text
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