HNSCC cell lines positive for HPV and p16 possess higher cellular radiosensitivity due to an impaired DSB repair capacity

When treated by radiotherapy, patients with squamous cell carcinomas of the head and neck (HNSCC) positive for HPV and p16INK4a possess a clearly favorable prognosis as compared to those with HPV-negative HNSCC. The aim of this work was to study whether the better outcomes might be caused by an enha...

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Bibliographic Details
Published in:	Radiotherapy and oncology Vol. 107; no. 2; pp. 242 - 246
Main Authors:	Rieckmann, Thorsten, Tribius, Silke, Grob, Tobias J., Meyer, Felix, Busch, Chia-Jung, Petersen, Cordula, Dikomey, Ekkehard, Kriegs, Malte
Format:	Journal Article
Language:	English
Published:	Ireland Elsevier Ireland Ltd 01.05.2013
Subjects:	Apoptosis Carcinoma, Squamous Cell - chemistry Carcinoma, Squamous Cell - genetics Carcinoma, Squamous Cell - radiotherapy Carcinoma, Squamous Cell - virology Cell Line, Tumor Cyclin-Dependent Kinase Inhibitor p16 DNA Breaks, Double-Stranded DNA Repair G1 Phase Head and Neck Neoplasms - chemistry Head and Neck Neoplasms - genetics Head and Neck Neoplasms - radiotherapy Head and Neck Neoplasms - virology Hematology, Oncology, and Palliative Medicine HNSCC HPV Humans Neoplasm Proteins - analysis p16INK4a Papillomaviridae - isolation & purification Radiation Tolerance Radiosensitivity Squamous Cell Carcinoma of Head and Neck Radiosensitivity p16INK4a HNSCC HPV p16 INK4a
ISSN:	0167-8140, 1879-0887, 1879-0887
Online Access:	Get full text
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