17β-Estradiol sensitizes ovarian surface epithelium to transformation by suppressing Disabled-2 expression

Estrogen replacement therapy increases the risk of human ovarian cancer and exogenous estradiol accelerates the onset of ovarian cancer in mouse models. This study uses primary cultures of mouse ovarian surface epithelium (OSE) to demonstrate that one possible mechanism by which estrogen accelerates...

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Bibliographic Details
Published in:	Scientific reports Vol. 7; no. 1; pp. 16702 - 12
Main Authors:	Vuong, Nhung H., Salah Salah, Omar, Vanderhyden, Barbara C.
Format:	Journal Article
Language:	English
Published:	London Nature Publishing Group UK 01.12.2017 Nature Publishing Group
Subjects:	13 13/106 13/51 14/19 14/63 17β-Estradiol 38 38/109 38/61 631/443/494/2732/2730 631/67/1517/1709 631/80/304 64 64/60 82/1 Adaptor Proteins, Signal Transducing Adaptor Proteins, Vesicular Transport - biosynthesis Adaptor Proteins, Vesicular Transport - genetics Animal models Animals Apoptosis Regulatory Proteins Carcinoma, Ovarian Epithelial - chemically induced Carcinoma, Ovarian Epithelial - genetics Carcinoma, Ovarian Epithelial - metabolism Carcinoma, Ovarian Epithelial - pathology Cell proliferation Cell Transformation, Neoplastic - chemically induced Cell Transformation, Neoplastic - genetics Cell Transformation, Neoplastic - metabolism Cell Transformation, Neoplastic - pathology Contact inhibition Dysplasia Epithelial Cells - metabolism Epithelial Cells - pathology Epithelium Epithelium - metabolism Epithelium - pathology Estradiol - adverse effects Estradiol - pharmacology Estrogen receptors Estrogen replacement therapy Estrogens Female Genetic transformation Hormone replacement therapy Humanities and Social Sciences Humans Mice Mice, Knockout miRNA multidisciplinary Ovarian cancer Ovarian Neoplasms - chemically induced Ovarian Neoplasms - genetics Ovarian Neoplasms - metabolism Ovarian Neoplasms - pathology Ovary - metabolism Ovary - pathology Science Science (multidisciplinary) Senescence Tumor Suppressor Proteins - biosynthesis Tumor Suppressor Proteins - genetics Tumors
ISSN:	2045-2322, 2045-2322
Online Access:	Get full text
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