Blocking type TSH receptor antibodies

TSH receptor (TSHR) autoantibodies (TRAbs) play a key role in the pathogenesis of Graves’ disease. In the majority of patients, TRAbs stimulate thyroid hormone synthesis via activation of the TSHR (stimulating TRAbs, TSHR agonists). In some patients, TRAbs bind to the receptor but do not cause activ...

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Bibliographic Details
Published in:	Autoimmunity highlights Vol. 4; no. 1; pp. 11 - 26
Main Authors:	Furmaniak, Jadwiga, Sanders, Jane, Rees Smith, Bernard
Format:	Journal Article
Language:	English
Published:	Cham Springer International Publishing 01.04.2013 Springer Nature B.V
Subjects:	Antagonists Autoantibodies Biomedical and Life Sciences Biomedicine Drug delivery Graves' disease Hyperthyroidism Immunology Monoclonal antibodies Review Review Article Secretion Thyroid Thyroid gland Thyroid-stimulating hormone Thyroid-stimulating hormone receptors Autoimmunity Graves’ disease Thyroid stimulating autoantibody Thyroid blocking autoantibody TSH receptor
ISSN:	2038-0305, 2038-3274
Online Access:	Get full text
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