Neurotoxicity Associated with CD19-Targeted CAR-T Cell Therapies

Neurotoxicity is an important and common complication of chimeric antigen receptor-T cell therapies. Acute neurologic signs and/or symptoms occur in a significant proportion of patients treated with CD19-directed chimeric antigen receptor-T cells for B-cell malignancies. Clinical manifestations incl...

Ausführliche Beschreibung

Gespeichert in:

Bibliographische Detailangaben
Veröffentlicht in:	CNS drugs Jg. 32; H. 12; S. 1091 - 1101
Hauptverfasser:	Gust, Juliane, Taraseviciute, Agne, Turtle, Cameron J.
Format:	Journal Article
Sprache:	Englisch
Veröffentlicht:	Cham Springer International Publishing 01.12.2018 Springer Nature B.V
Schlagworte:	Animal models Antigens Antigens, CD19 - metabolism Arthritis Blood-brain barrier Brain cancer CD19 antigen Cell activation Cell therapy Cerebrospinal fluid Chimeric antigen receptors Clinical trials Corticosteroids Cytokines Cytokines - blood Cytokines - cerebrospinal fluid Edema FDA approval Headache Humans Immunologic Factors - therapeutic use Immunotherapy Immunotherapy, Adoptive - methods Interleukin 6 Leading Article Leukemia Lymphocytes Lymphocytes B Lymphocytes T Lymphoma Medicine Medicine & Public Health Multiple myeloma Neurology Neurosciences Neurotoxicity Neurotoxicity Syndromes - epidemiology Neurotoxicity Syndromes - immunology Neurotoxicity Syndromes - metabolism Neurotoxicity Syndromes - therapy Pediatrics Pharmacotherapy Psychiatry Psychopharmacology Receptors, Antigen, T-Cell - metabolism Seizures Traumatic brain injury Young adults United States > US
ISSN:	1172-7047, 1179-1934, 1179-1934
Online-Zugang:	Volltext
Tags:	Tag hinzufügen Keine Tags, Fügen Sie den ersten Tag hinzu!

Schreiben Sie den ersten Kommentar!