Eicosanoid-Activated PPARα Inhibits NFκB-Dependent Bacterial Clearance During Post-Influenza Superinfection

Secondary bacterial infection (superinfection) post influenza is a serious clinical complication often leading to pneumonia and death. Eicosanoids are bioactive lipid mediators that play critical roles in the induction and resolution of inflammation. CYP450 lipid metabolites are anti-inflammatory li...

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Veröffentlicht in:	Frontiers in cellular and infection microbiology Jg. 12; S. 881462
Hauptverfasser:	Lucarelli, Ronald, Gorrochotegui-Escalante, Norma, Taddeo, Jessica, Buttaro, Bettina, Beld, Joris, Tam, Vincent
Format:	Journal Article
Sprache:	Englisch
Veröffentlicht:	Lausanne Frontiers Media SA 04.07.2022 Frontiers Media S.A
Schlagworte:	Antibacterial activity Bacterial infections Cellular and Infection Microbiology Cytochrome P450 eicosanoid Eicosanoids Inflammation Influenza innate immunity lipidomic Lipids Macrophages Metabolites Mortality NF-κB protein Nuclear transport Phosphorylation Staphylococcus aureus Superinfection Toll-like receptors Transcription activation
ISSN:	2235-2988, 2235-2988
Online-Zugang:	Volltext
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