Brain Energy Metabolism in Two States of Mind Measured by Phosphorous Magnetic Resonance Spectroscopy

Introduction: Various functional neuroimaging studies help to better understand the changes in brain activity during meditation. The purpose of this study was to investigate how brain energy metabolism changes during focused attention meditation (FAM) state, measured by phosphorous magnetic resonanc...

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Veröffentlicht in:Frontiers in human neuroscience Jg. 15; S. 686433
Hauptverfasser: Galijašević, Malik, Steiger, Ruth, Regodić, Milovan, Waibel, Michaela, Sommer, Patrick Julian David, Grams, Astrid Ellen, Singewald, Nicolas, Gizewski, Elke Ruth
Format: Journal Article
Sprache:Englisch
Veröffentlicht: Lausanne Frontiers Research Foundation 28.06.2021
Frontiers Media S.A
Schlagworte:
Basal ganglia
Brain
brain energy metabolism
Energy
Energy metabolism
Human Neuroscience
Investigations
magnetic resonance
Magnetic resonance imaging
Magnetic resonance spectroscopy
Meditation
Metabolism
Metabolites
Mindfulness
Neuroimaging
phosphorous
spectroscopy
Spectrum analysis
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ISSN:1662-5161, 1662-5161
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Zusammenfassung:Introduction: Various functional neuroimaging studies help to better understand the changes in brain activity during meditation. The purpose of this study was to investigate how brain energy metabolism changes during focused attention meditation (FAM) state, measured by phosphorous magnetic resonance spectroscopy ( 31 P-MRS). Methods: 31 P-MRS imaging was carried out in 27 participants after 7 weeks of FAM training. Metabolite ratios and the absolute values of metabolites were assessed after meditation training in two MRI measurements, by comparing effects in a FAM state with those in a distinct focused attention awake state during a backwards counting task. Results: The results showed decreased phosphocreatine/ATP (PCr/ATP), PCr/ inorganic phosphate (Pi), and intracellular pH values in the entire brain, but especially in basal ganglia, frontal lobes, and occipital lobes, and increased Pi/ATP ratio, cerebral Mg, and Pi absolute values were found in the same areas during FAM compared to the control focused attention awake state. Conclusions: Changes in the temporal areas and basal ganglia may be interpreted as a higher energetic state induced by meditation, whereas the frontal and occipital areas showed changes that may be related to a down-regulation in ATP turnover, energy state, and oxidative capacity.
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Reviewed by: Eva-Maria Ratai, Massachusetts General Hospital and Harvard Medical School, United States; Paulo A. S. Armada-da-Silva, Universidade de Lisboa, Portugal
This article was submitted to Brain Imaging and Stimulation, a section of the journal Frontiers in Human Neuroscience
Edited by: Zhen Yuan, University of Macau, China
ISSN:1662-5161
1662-5161
DOI:10.3389/fnhum.2021.686433