DNA sequence-level analyses reveal potential phenotypic modifiers in a large family with psychiatric disorders

Psychiatric disorders are a group of genetically related diseases with highly polygenic architectures. Genome-wide association analyses have made substantial progress towards understanding the genetic architecture of these disorders. More recently, exome- and whole-genome sequencing of cases and fam...

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Veröffentlicht in:	Molecular psychiatry Jg. 23; H. 12; S. 2254 - 2265
Hauptverfasser:	Ryan, Niamh M, Lihm, Jayon, Kramer, Melissa, McCarthy, Shane, Morris, Stewart W, Arnau-Soler, Aleix, Davies, Gail, Duff, Barbara, Ghiban, Elena, Hayward, Caroline, Deary, Ian J, Blackwood, Douglas H R, Lawrie, Stephen M, McIntosh, Andrew M, Evans, Kathryn L, Porteous, David J, McCombie, W Richard, Thomson, Pippa A
Format:	Journal Article
Sprache:	Englisch
Veröffentlicht:	England Nature Publishing Group 01.12.2018
Schlagworte:	Adult Alleles Behavior disorders Cognition Contactins - genetics Cyclic Nucleotide Phosphodiesterases, Type 4 - genetics Disc1 protein Family - psychology Female Gene frequency Gene Frequency - genetics Genetic diversity Genetic Linkage - genetics Genetic Predisposition to Disease - genetics Genetic Testing Genome-Wide Association Study Genomes Genomics Genotype Heritability Humans Linkage analysis Lod Score Male Mental disorders Mental Disorders - genetics Mental Disorders - physiopathology Middle Aged Mood Disorders - genetics Multifactorial Inheritance Nerve Tissue Proteins - genetics Neuroimaging Nucleotide sequence Pedigree Phenotype Phenotypes Phenotypic variations Phosphodiesterase Receptor, Metabotropic Glutamate 5 - genetics Recombinant Fusion Proteins - genetics RNA, Long Noncoding RNA, Messenger - genetics Sequence Analysis, DNA - methods Translocation, Genetic
ISSN:	1359-4184, 1476-5578, 1476-5578
Online-Zugang:	Volltext
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