Structure and activation of the TSH receptor transmembrane domain

Purpose The thyroid-stimulating hormone receptor (TSHR) is the target autoantigen for TSHR-stimulating autoantibodies in Graves’ disease. The TSHR is composed of: a leucine-rich repeat domain (LRD), a hinge region or cleavage domain (CD) and a transmembrane domain (TMD). The binding arrangements bet...

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Bibliographic Details
Published in:	Autoimmunity highlights Vol. 8; no. 1; p. 2
Main Authors:	Núñez Miguel, Ricardo, Sanders, Jane, Furmaniak, Jadwiga, Smith, Bernard Rees
Format:	Journal Article
Language:	English
Published:	Cham Springer International Publishing 01.12.2017 Springer Nature B.V
Subjects:	Autoantibodies Biomedical and Life Sciences Biomedicine Crystal structure Follicle-stimulating hormone G protein-coupled receptors Graves' disease Immunology Leucine Luteinizing hormone Original Original Article Thyroid Thyroid gland Thyroid-stimulating hormone Thyroid-stimulating hormone receptors Transmembrane domains TSHR structure Glycoprotein hormones Graves’ disease TSHR activation Transmembrane domain structure Glycoprotein hormone receptors
ISSN:	2038-0305, 2038-3274
Online Access:	Get full text
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