Are DXA/aBMD and QCT/FEA Stiffness and Strength Estimates Sensitive to Sex and Age?

Dual X-ray absorptiometry (DXA) measures areal bone mineral density (aBMD) by simplifying a complex 3D bone structure to a 2D projection and is not equally effective for explaining fracture strength in women and men. Unlike DXA, subject-specific quantitative computed tomography-based finite element...

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Vydáno v:	Annals of biomedical engineering Ročník 45; číslo 12; s. 2847 - 2856
Hlavní autoři:	Rezaei, Asghar, Giambini, Hugo, Rossman, Timothy, Carlson, Kent D., Yaszemski, Michael J., Lu, Lichun, Dragomir-Daescu, Dan
Médium:	Journal Article
Jazyk:	angličtina
Vydáno:	New York Springer US 01.12.2017 Springer Nature B.V
Témata:	Absorptiometry Absorptiometry, Photon - methods Adult Age Aged Aged, 80 and over Aging - physiology Biochemistry Biological and Medical Physics Biomedical and Life Sciences Biomedical Engineering and Bioengineering Biomedical materials Biomedicine Biophysics Bone mineral density Cadaver Cadavers Calcification, Physiologic - physiology Classical Mechanics Compressive Strength - physiology Computed tomography Computer Simulation Dual energy X-ray absorptiometry Elastic Modulus - physiology Estimates Female Femur Femur - diagnostic imaging Femur - physiology Finite Element Analysis Finite element method Forecasting Fracture strength Fractures Hip Humans Male Mechanical properties Middle Aged Models, Biological Position measurement Reproducibility of Results Sensitivity analysis Sensitivity and Specificity Sex Sex Characteristics Statistical analysis Stiffness Stress, Mechanical Surgical implants Tensile Strength - physiology Tomography, X-Ray Computed - methods Aging Sex differences Hip fracture Finite element analysis Bone biomechanics
ISSN:	0090-6964, 1573-9686, 1573-9686
On-line přístup:	Získat plný text
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Popis
Shrnutí:	Dual X-ray absorptiometry (DXA) measures areal bone mineral density (aBMD) by simplifying a complex 3D bone structure to a 2D projection and is not equally effective for explaining fracture strength in women and men. Unlike DXA, subject-specific quantitative computed tomography-based finite element analysis (QCT/FEA) estimates fracture strength using 3D bone mineral distribution and geometry. By using experimentally-measured femoral stiffness and strength from a one hundred sample cadaveric cohort that included variations in sex and age, we wanted to determine if QCT/FEA estimates were able to better predict the experimental variations than DXA/aBMD. For each femur, DXA/aBMD was assessed and a QCT/FEA model was developed to estimate femoral stiffness and strength. Then, the femur was mechanically tested to fracture in a sideways fall on the hip position to measure stiffness and strength. DXA/aBMD and QCT/FEA estimates were compared for their sensitivity to sex and age with multivariate statistical analyses. When comparing the measured data with DXA/aBMD predictions, both age and sex were significant ( p ≤ 0.0398) for both femoral stiffness and strength. However, QCT/FEA predictions of stiffness and strength showed sex was insignificant ( p ≥ 0.23). Age was still significant ( p ≤ 0.0072). These results indicate that QCT/FEA, unlike DXA/aBMD, accounted for bone differences due to sex.
Bibliografie:	ObjectType-Article-1 SourceType-Scholarly Journals-1 ObjectType-Feature-2 content type line 14 ObjectType-Article-2 ObjectType-Feature-1 content type line 23 ObjectType-Undefined-3
ISSN:	0090-6964 1573-9686 1573-9686
DOI:	10.1007/s10439-017-1914-5