Prevalence and prognosis of hypoxia‐inducible factor‐2α (HIF‐2α) pathway gene mutations across advanced solid tumors

Introduction Hypoxia‐inducible factor‐2α (HIF‐2α) modulates the hypoxic response pathway in tumors; however, mutations in pathways (including SDHA, SDHB, SDHC, SDHD, FH, and VHL genes) that are suspected to activate HIF‐2α are poorly understood, with limited understanding of the prevalence and clini...

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Bibliographic Details
Published in:	Cancer medicine (Malden, MA) Vol. 13; no. 11; pp. e7358 - n/a
Main Authors:	Zhong, Wenjun, Ma, Jiemin, Chen, Cai, Dettman, E. J., Cristescu, Razvan, Naik, Girish S., Jin, Fan, Shao, Changxia
Format:	Journal Article
Language:	English
Published:	United States John Wiley & Sons, Inc 01.06.2024 John Wiley and Sons Inc Wiley
Subjects:	Adult Aged Basic Helix-Loop-Helix Transcription Factors - genetics Bladder cancer Cancer therapies Colorectal cancer Datasets Electronic health records Endometrial cancer epidemiology Female Gastric cancer Genes HIF‐2α Humans Hypoxia Hypoxia-inducible factors Kidney cancer Liver cancer Lung cancer Male Medical prognosis Melanoma Mesothelioma Metastases Metastasis Middle Aged Mutation Neoplasms - epidemiology Neoplasms - genetics Neoplasms - mortality Neoplasms - pathology oncology Ovaries Patients Point mutation Population Population studies Prevalence Prognosis Prostate Renal cell carcinoma Retrospective Studies Solid tumors Tumors United States > US epidemiology prevalence HIF‐2α prognosis oncology
ISSN:	2045-7634, 2045-7634
Online Access:	Get full text
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