Is Low Serum Klotho Level Associated with Alterations in Coronary Flow Reserve?

Background The Klotho gene, described as an “aging suppressor” gene, encodes a single‐pass transmembrane protein. The extracellular part of Klotho is cleaved and released into the circulation where it may function as a vasculoprotective hormone. Coronary flow reserve (CFR) is accepted as a marker of...

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Veröffentlicht in:Echocardiography (Mount Kisco, N.Y.) Jg. 33; H. 6; S. 881 - 888
Hauptverfasser: Keles, Nursen, Caliskan, Mustafa, Dogan, Burcu, Aksu, Feyza, Bulur, Serkan, Keles, Necibe Nur, Kostek, Osman, Aung, Soe Moe, Isbilen, Banu, Demircioglu, Kenan, Kalcik, Macit, Oguz, Aytekin
Format: Journal Article
Sprache:Englisch
Veröffentlicht: United States Blackwell Publishing Ltd 01.06.2016
Schlagworte:
Adult
Biomarkers - blood
Blood Flow Velocity
coronary artery disease
Coronary Artery Disease - blood
Coronary Artery Disease - diagnostic imaging
Coronary Circulation
coronary flow reserve
Echocardiography - methods
Female
Fractional Flow Reserve, Myocardial
Glucuronidase - blood
Humans
Klotho
Male
Microvessels - diagnostic imaging
Microvessels - physiopathology
Reproducibility of Results
Sensitivity and Specificity
coronary artery disease
Klotho
coronary flow reserve
ISSN:0742-2822, 1540-8175, 1540-8175
Online-Zugang:Volltext
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Zusammenfassung:Background The Klotho gene, described as an “aging suppressor” gene, encodes a single‐pass transmembrane protein. The extracellular part of Klotho is cleaved and released into the circulation where it may function as a vasculoprotective hormone. Coronary flow reserve (CFR) is accepted as a marker of coronary microvascular dysfunction when epicardial coronary stenosis is absent. There are no data regarding the relationship between serum Klotho levels and disorders in coronary microcirculation in healthy adults. We aimed to investigate the association between serum Klotho levels and alterations in coronary microcirculation in healthy adults using echocardiographic measurements of CFR. Methods Thirty‐four healthy volunteers (median age: 34 [27–39], 14 males) were enrolled in this study. The study population was divided into two subgroups according to the median value of serum Klotho levels: a high Klotho (HK) group (n = 17, median age: 34 [30–38]; 6 males) and a low Klotho (LK) group (n = 17, median age: 32 [26–39]; 8 males). The analysis of coronary flow velocities was performed by transthoracic Doppler echocardiography. Results Hyperemic diastolic peak flow velocities and CFR were significantly higher in the HK group than in the LK group (70 [66–92] versus 61 [47–66], P = 0.003 and 3.0 [2.6–3.8] versus 2.2 [1.7–2.8], respectively, P = 0.001). Serum Klotho levels were positively correlated with CFR (P < 0.001). Conclusion Serum Klotho levels correlate with CFR in a healthy population. Low serum Klotho levels may potentially identify patients with impaired CFR.
Bibliographie:ArticleID:ECHO13176
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ObjectType-Article-1
SourceType-Scholarly Journals-1
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content type line 23
ISSN:0742-2822
1540-8175
1540-8175
DOI:10.1111/echo.13176