Linsitinib, an IGF-1R inhibitor, attenuates disease development and progression in a model of thyroid eye disease

Graves' disease (GD) is an autoimmune disorder caused by autoantibodies against the thyroid stimulating hormone receptor (TSHR) leading to overstimulation of the thyroid gland. Thyroid eye disease (TED) is the most common extra thyroidal manifestation of GD. Therapeutic options to treat TED are...

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Veröffentlicht in:	Frontiers in endocrinology (Lausanne) Jg. 14; S. 1211473
Hauptverfasser:	Gulbins, Anne, Horstmann, Mareike, Daser, Anke, Flögel, Ulrich, Oeverhaus, Michael, Bechrakis, Nikolaos E., Banga, J. Paul, Keitsch, Simone, Wilker, Barbara, Krause, Gerd, Hammer, Gary D., Spencer, Andrew G., Zeidan, Ryan, Eckstein, Anja, Philipp, Svenja, Görtz, Gina-Eva
Format:	Journal Article
Sprache:	Englisch
Veröffentlicht:	Switzerland Frontiers Media S.A 26.06.2023
Schlagworte:	autoimmune disorder Endocrinology Graves’ disease (GD) IGF-1R inflammation linsitinib thyroid eye disease (TED) Graves’ disease (GD) thyroid eye disease (TED) IGF-1R inflammation autoimmune disorder linsitinib
ISSN:	1664-2392, 1664-2392
Online-Zugang:	Volltext
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