α-klotho reduces susceptibility to osteoarthritis: evidence from cross-sectional studies and Mendelian randomization

Despite extensive research, the association between serum α-klotho levels and osteoarthritis (OA) remains unclear, predominantly relying on findings from OA mouse models. This study used data from the National Health and Nutrition Examination Survey (NHANES) to conduct a cross-sectional study examin...

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Bibliographic Details
Published in:	Frontiers in endocrinology (Lausanne) Vol. 15; p. 1450472
Main Authors:	Li, Zhao, Li, Zhong, Cheng, Qisheng, Nie, Xinlin, Cui, Yu, Du, Bing, Ren, Taotao, Xu, Yibo, Ma, Teng
Format:	Journal Article
Language:	English
Published:	Switzerland Frontiers Media S.A 19.11.2024
Subjects:	Adult Aged causal effect Cohort Studies Cross-Sectional Studies Disease Susceptibility Endocrinology Female Genetic Predisposition to Disease Glucuronidase - blood Glucuronidase - genetics Humans Klotho Proteins Male Mendelian randomization Mendelian Randomization Analysis Middle Aged NHANES Nutrition Surveys osteoarthritis Osteoarthritis - blood Osteoarthritis - genetics Osteoarthritis - metabolism α-klotho α-klotho NHANES causal effect Mendelian randomization osteoarthritis
ISSN:	1664-2392, 1664-2392
Online Access:	Get full text
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