Long-lasting improvements in episodic memory among subjects with mild cognitive impairment who received transcranial direct current stimulation combined with cognitive treatment and telerehabilitation: a multicentre, randomized, active-controlled study

In recent years, an increasing number of studies have examined the potential efficacy of cognitive training procedures in individuals with normal ageing and mild cognitive impairment (MCI). The aims of this study were to (i) evaluate the efficacy of the cognitive Virtual Reality Rehabilitation Syste...

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Published in:Frontiers in aging neuroscience Vol. 16; p. 1414593
Main Authors: Manenti, Rosa, Baglio, Francesca, Pagnoni, Ilaria, Gobbi, Elena, Campana, Elena, Alaimo, Cristina, Rossetto, Federica, Di Tella, Sonia, Pagliari, Chiara, Geviti, Andrea, Bonfiglio, Natale Salvatore, Calabrò, Rocco Salvatore, Cimino, Vincenzo, Binetti, Giuliano, Quartarone, Angelo, Bramanti, Placido, Cappa, Stefano F., Rossini, Paolo Maria, Cotelli, Maria
Format: Journal Article
Language:English
Published: Switzerland Frontiers Media S.A 18.06.2024
Subjects:
Aging Neuroscience
cognition
MCI
tDCS
telerehabilitation
transcranial direct current stimulation
MCI
cognition
tDCS
telerehabilitation
transcranial direct current stimulation
ISSN:1663-4365, 1663-4365
Online Access:Get full text
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Summary:In recent years, an increasing number of studies have examined the potential efficacy of cognitive training procedures in individuals with normal ageing and mild cognitive impairment (MCI). The aims of this study were to (i) evaluate the efficacy of the cognitive Virtual Reality Rehabilitation System (VRRS) combined with anodal transcranial direct current stimulation (tDCS) applied to the left dorsolateral prefrontal cortex compared to placebo tDCS stimulation combined with VRRS and (ii) to determine how to prolong the beneficial effects of the treatment. A total of 109 subjects with MCI were assigned to 1 of 5 study groups in a randomized controlled trial design: (a) face-to-face (FTF) VRRS during anodal tDCS followed by cognitive telerehabilitation (TR) (clinic-atDCS-VRRS+Tele@H-VRRS); (b) FTF VRRS during placebo tDCS followed by TR (clinic-ptDCS-VRRS+Tele@H-VRRS); (c) FTF VRRS followed by cognitive TR (clinic-VRRS+Tele@H-VRRS); (d) FTF VRRS followed by at-home unstructured cognitive stimulation (clinic-VRRS+@H-UCS); and (e) FTF cognitive treatment as usual (clinic-TAU). An improvement in episodic memory was observed after the end of clinic-atDCS-VRRS (  < 0.001). We found no enhancement in episodic memory after clinic-ptDCS-VRRS or after clinic-TAU.Moreover, the combined treatment led to prolonged beneficial effects (clinic-atDCS-VRRS+Tele@H-VRRS vs. clinic-ptDCS-VRRS+Tele@H-VRRS:  = 0.047; clinic-atDCS-VRRS+Tele@H-VRRS vs. clinic-VRRS+Tele@H-VRRS:  = 0.06). The present study provides preliminary evidence supporting the use of individualized VRRS combined with anodal tDCS and cognitive telerehabilitation for cognitive rehabilitation. https://clinicaltrials.gov/study/NCT03486704?term=NCT03486704&rank=1, NCT03486704.
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Edited by: Antonio Ivano Triggiani, National Institute of Neurological Disorders and Stroke (NIH), United States
Reviewed by: John Dimitrios Papatriantafyllou, Third Age Day-Care Center, IASIS, Greece
Marina Bluma, Karolinska Institutet, Sweden
ISSN:1663-4365
1663-4365
DOI:10.3389/fnagi.2024.1414593