Pilot clinical trial of neoadjuvant toll-like receptor 7 agonist (Imiquimod) immunotherapy in early-stage oral squamous cell carcinoma

There is no neoadjuvant immunotherapy for early-stage oral cancer patients. We report a single-arm, open-label, pilot clinical trial assessing the efficacy and safety of topical toll-like receptor-7 (TLR-7) agonist, imiquimod, utilized in a neoadjuvant setting in early-stage oral squamous cell carci...

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Bibliographic Details
Published in:	Frontiers in immunology Vol. 16; p. 1530262
Main Authors:	Yoon, Angela J., Carvajal, Richard D., Graboyes, Evan M., Kaczmar, John M., Albergotti, William G., Kejner, Alexandra E., Troob, Scott H., Philipone, Elizabeth, Anoma, Jean-Sebastien, Armeson, Kent E., Hill, Elizabeth G., Richardson, Mary S., Woods, Tina R., Chera, Bhishamjit S., Nourollah-Zadeh, Farzad, Lee, Byung J., Pandruvada, Subramanya, Kourtidis, Antonis, Kingsley, Christina, O’Quinn, Elizabeth C., Mills, Stephanie, Jordan, Victoria C., Spencer, Mike, Fails, Danielle, McKee, Trevor D., Zaidi, Mark, Brisendine, Alan, Horn, Shane, Mehrotra, Shikhar, Ogretmen, Besim, Newman, Jason G.
Format:	Journal Article
Language:	English
Published:	Switzerland Frontiers Media S.A 2025
Subjects:	Adult Aged Female Humans imiquimod Imiquimod - administration & dosage Imiquimod - adverse effects Imiquimod - therapeutic use Immunology immunotherapy Immunotherapy - methods Male Middle Aged Mouth Neoplasms - drug therapy Mouth Neoplasms - immunology Mouth Neoplasms - pathology neoadjuvant clinical trial Neoadjuvant Therapy Neoplasm Staging oral cancer Pilot Projects toll-like 7 receptor agonist Toll-Like Receptor 7 - agonists Treatment Outcome neoadjuvant clinical trial toll-like 7 receptor agonist oral cancer imiquimod immunotherapy
ISSN:	1664-3224, 1664-3224
Online Access:	Get full text
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