Acne and risk of mental disorders: A two-sample Mendelian randomization study based on large genome-wide association data
Despite a growing body of evidence that acne impacts mental disorders, the actual causality has not been established for the possible presence of recall bias and confounders in observational studies. We performed a two-sample Mendelian randomization (MR) analysis to evaluate the effect of acne on th...
Uloženo v:
| Vydáno v: | Frontiers in public health Ročník 11; s. 1156522 |
|---|---|
| Hlavní autoři: | , , , , , , |
| Médium: | Journal Article |
| Jazyk: | angličtina |
| Vydáno: |
Switzerland
Frontiers Media S.A
31.03.2023
|
| Témata: | |
| ISSN: | 2296-2565, 2296-2565 |
| On-line přístup: | Získat plný text |
| Tagy: |
Přidat tag
Žádné tagy, Buďte první, kdo vytvoří štítek k tomuto záznamu!
|
| Abstract | Despite a growing body of evidence that acne impacts mental disorders, the actual causality has not been established for the possible presence of recall bias and confounders in observational studies.
We performed a two-sample Mendelian randomization (MR) analysis to evaluate the effect of acne on the risk of six common mental disorders, i.e., depression, anxiety, schizophrenia, obsessive-compulsive disorder (OCD), bipolar disorder, and post-traumatic stress disorder (PTSD). We acquired genetic instruments for assessing acne from the largest genome-wide association study (GWAS) of acne (
= 615,396) and collected summary statistics from the largest available GWAS for depression (
= 500,199), anxiety (
= 17,310), schizophrenia (
= 130,644), OCD (
= 9,725), bipolar disorder (
= 413,466), and PTSD (
= 174,659). Next, we performed the two-sample MR analysis using four methods: inverse-variance weighted method, MR-Egger, weighted median, and MR pleiotropy residual sum and outliers. Sensitivity analysis was also performed for heterogeneity and pleiotropy tests.
There was no evidence of a causal impact of acne on the risk of depression [odds ratio (OR): 1.002,
= 0.874], anxiety (OR: 0.961,
= 0.49), OCD (OR: 0.979,
= 0.741), bipolar disorder (OR: 0.972,
= 0.261), and PTSD (OR: 1.054,
= 0.069). Moreover, a mild protective effect of acne against schizophrenia was observed (OR: 0.944;
= 0.033).
The increased prevalence of mental disorders observed in patients with acne in clinical practice was caused by modifiable factors, and was not a direct outcome of acne. Therefore, strategies targeting the elimination of potential factors and minimization of the occurrence of adverse mental events in acne should be implemented. |
|---|---|
| AbstractList | BackgroundDespite a growing body of evidence that acne impacts mental disorders, the actual causality has not been established for the possible presence of recall bias and confounders in observational studies.MethodsWe performed a two-sample Mendelian randomization (MR) analysis to evaluate the effect of acne on the risk of six common mental disorders, i.e., depression, anxiety, schizophrenia, obsessive–compulsive disorder (OCD), bipolar disorder, and post-traumatic stress disorder (PTSD). We acquired genetic instruments for assessing acne from the largest genome-wide association study (GWAS) of acne (N = 615,396) and collected summary statistics from the largest available GWAS for depression (N = 500,199), anxiety (N = 17,310), schizophrenia (N = 130,644), OCD (N = 9,725), bipolar disorder (N = 413,466), and PTSD (N = 174,659). Next, we performed the two-sample MR analysis using four methods: inverse-variance weighted method, MR-Egger, weighted median, and MR pleiotropy residual sum and outliers. Sensitivity analysis was also performed for heterogeneity and pleiotropy tests.ResultsThere was no evidence of a causal impact of acne on the risk of depression [odds ratio (OR): 1.002, p = 0.874], anxiety (OR: 0.961, p = 0.49), OCD (OR: 0.979, p = 0.741), bipolar disorder (OR: 0.972, p = 0.261), and PTSD (OR: 1.054, p = 0.069). Moreover, a mild protective effect of acne against schizophrenia was observed (OR: 0.944; p = 0.033).ConclusionThe increased prevalence of mental disorders observed in patients with acne in clinical practice was caused by modifiable factors, and was not a direct outcome of acne. Therefore, strategies targeting the elimination of potential factors and minimization of the occurrence of adverse mental events in acne should be implemented. Despite a growing body of evidence that acne impacts mental disorders, the actual causality has not been established for the possible presence of recall bias and confounders in observational studies. We performed a two-sample Mendelian randomization (MR) analysis to evaluate the effect of acne on the risk of six common mental disorders, i.e., depression, anxiety, schizophrenia, obsessive-compulsive disorder (OCD), bipolar disorder, and post-traumatic stress disorder (PTSD). We acquired genetic instruments for assessing acne from the largest genome-wide association study (GWAS) of acne ( = 615,396) and collected summary statistics from the largest available GWAS for depression ( = 500,199), anxiety ( = 17,310), schizophrenia ( = 130,644), OCD ( = 9,725), bipolar disorder ( = 413,466), and PTSD ( = 174,659). Next, we performed the two-sample MR analysis using four methods: inverse-variance weighted method, MR-Egger, weighted median, and MR pleiotropy residual sum and outliers. Sensitivity analysis was also performed for heterogeneity and pleiotropy tests. There was no evidence of a causal impact of acne on the risk of depression [odds ratio (OR): 1.002, = 0.874], anxiety (OR: 0.961, = 0.49), OCD (OR: 0.979, = 0.741), bipolar disorder (OR: 0.972, = 0.261), and PTSD (OR: 1.054, = 0.069). Moreover, a mild protective effect of acne against schizophrenia was observed (OR: 0.944; = 0.033). The increased prevalence of mental disorders observed in patients with acne in clinical practice was caused by modifiable factors, and was not a direct outcome of acne. Therefore, strategies targeting the elimination of potential factors and minimization of the occurrence of adverse mental events in acne should be implemented. Despite a growing body of evidence that acne impacts mental disorders, the actual causality has not been established for the possible presence of recall bias and confounders in observational studies.BackgroundDespite a growing body of evidence that acne impacts mental disorders, the actual causality has not been established for the possible presence of recall bias and confounders in observational studies.We performed a two-sample Mendelian randomization (MR) analysis to evaluate the effect of acne on the risk of six common mental disorders, i.e., depression, anxiety, schizophrenia, obsessive-compulsive disorder (OCD), bipolar disorder, and post-traumatic stress disorder (PTSD). We acquired genetic instruments for assessing acne from the largest genome-wide association study (GWAS) of acne (N = 615,396) and collected summary statistics from the largest available GWAS for depression (N = 500,199), anxiety (N = 17,310), schizophrenia (N = 130,644), OCD (N = 9,725), bipolar disorder (N = 413,466), and PTSD (N = 174,659). Next, we performed the two-sample MR analysis using four methods: inverse-variance weighted method, MR-Egger, weighted median, and MR pleiotropy residual sum and outliers. Sensitivity analysis was also performed for heterogeneity and pleiotropy tests.MethodsWe performed a two-sample Mendelian randomization (MR) analysis to evaluate the effect of acne on the risk of six common mental disorders, i.e., depression, anxiety, schizophrenia, obsessive-compulsive disorder (OCD), bipolar disorder, and post-traumatic stress disorder (PTSD). We acquired genetic instruments for assessing acne from the largest genome-wide association study (GWAS) of acne (N = 615,396) and collected summary statistics from the largest available GWAS for depression (N = 500,199), anxiety (N = 17,310), schizophrenia (N = 130,644), OCD (N = 9,725), bipolar disorder (N = 413,466), and PTSD (N = 174,659). Next, we performed the two-sample MR analysis using four methods: inverse-variance weighted method, MR-Egger, weighted median, and MR pleiotropy residual sum and outliers. Sensitivity analysis was also performed for heterogeneity and pleiotropy tests.There was no evidence of a causal impact of acne on the risk of depression [odds ratio (OR): 1.002, p = 0.874], anxiety (OR: 0.961, p = 0.49), OCD (OR: 0.979, p = 0.741), bipolar disorder (OR: 0.972, p = 0.261), and PTSD (OR: 1.054, p = 0.069). Moreover, a mild protective effect of acne against schizophrenia was observed (OR: 0.944; p = 0.033).ResultsThere was no evidence of a causal impact of acne on the risk of depression [odds ratio (OR): 1.002, p = 0.874], anxiety (OR: 0.961, p = 0.49), OCD (OR: 0.979, p = 0.741), bipolar disorder (OR: 0.972, p = 0.261), and PTSD (OR: 1.054, p = 0.069). Moreover, a mild protective effect of acne against schizophrenia was observed (OR: 0.944; p = 0.033).The increased prevalence of mental disorders observed in patients with acne in clinical practice was caused by modifiable factors, and was not a direct outcome of acne. Therefore, strategies targeting the elimination of potential factors and minimization of the occurrence of adverse mental events in acne should be implemented.ConclusionThe increased prevalence of mental disorders observed in patients with acne in clinical practice was caused by modifiable factors, and was not a direct outcome of acne. Therefore, strategies targeting the elimination of potential factors and minimization of the occurrence of adverse mental events in acne should be implemented. |
| Author | Chen, Tingqiao Zhong, Judan Chen, Jin Shao, Xinyi Chen, Yangmei Xue, Yuzhou Liu, Lin |
| AuthorAffiliation | 1 Department of Dermatology, The First Affiliated Hospital of Chongqing Medical University , Chongqing , China 2 Department of Cardiology and Institute of Vascular Medicine, Peking University Third Hospital , Beijing , China |
| AuthorAffiliation_xml | – name: 2 Department of Cardiology and Institute of Vascular Medicine, Peking University Third Hospital , Beijing , China – name: 1 Department of Dermatology, The First Affiliated Hospital of Chongqing Medical University , Chongqing , China |
| Author_xml | – sequence: 1 givenname: Lin surname: Liu fullname: Liu, Lin – sequence: 2 givenname: Yuzhou surname: Xue fullname: Xue, Yuzhou – sequence: 3 givenname: Yangmei surname: Chen fullname: Chen, Yangmei – sequence: 4 givenname: Tingqiao surname: Chen fullname: Chen, Tingqiao – sequence: 5 givenname: Judan surname: Zhong fullname: Zhong, Judan – sequence: 6 givenname: Xinyi surname: Shao fullname: Shao, Xinyi – sequence: 7 givenname: Jin surname: Chen fullname: Chen, Jin |
| BackLink | https://www.ncbi.nlm.nih.gov/pubmed/37064666$$D View this record in MEDLINE/PubMed |
| BookMark | eNp9Ustu1DAUjVARLaU_wAJ5ySaDH7GTsEGjikelIjawtm7sm6mLYw92ptXw9bgz06rtgpV97fOQzj2vq6MQA1bVW0YXQnT9h3G9Ga4WnHKxYEwqyfmL6oTzXtW8TEeP7sfVWc7XlFJGRUM5e1Udi5aqRil1Um2XJiCBYEly-TeJI5kwzOCJdTkmiyl_JEsy38Y6w7T2SL5jsOgdBJIKK07uL8wuBpLnjd2SATJaUkYPaYVkhSFOWN86WzxyjsbtwRZmeFO9HMFnPDucp9WvL59_nn-rL398vThfXtamUf1cD7bDwUrFein7zvS9MII3arDc8G4EKoSQvWkZMxZ6yTrOZCuFlaNEJjg14rS62OvaCNd6ndwEaasjOL17iGmlIc3OeNTQjgqtBNFL3qAYQfBOtmJoZdcpEE3R-rTXKuFPaE2JKoF_Ivr0J7grvYo3mpXwudgpvD8opPhng3nWk8sGvYeAcZM17yhveFmPLNB3j80eXO6XVwDdHmBSzDnhqI2bdwEXb-eLqb6rit5VRd9VRR-qUqj8GfVe_T-kf7I6wzw |
| CitedBy_id | crossref_primary_10_3390_molecules30030515 crossref_primary_10_3389_fnut_2024_1404117 crossref_primary_10_1007_s12013_025_01780_9 crossref_primary_10_2147_CCID_S525621 crossref_primary_10_3389_fpsyt_2024_1351216 crossref_primary_10_4081_dr_2025_10191 crossref_primary_10_1093_ced_llae531 crossref_primary_10_1111_jocd_16763 |
| Cites_doi | 10.1111/dth.12795 10.1038/s41467-022-28252-5 10.1038/s41593-018-0326-7 10.1111/bjd.13462 10.1093/hmg/ddu328 10.1111/ddg.13664 10.1007/s40272-019-00340-y 10.5498/wjp.v5.i2.222 10.1111/jocd.14531 10.1016/j.jaad.2022.10.031 10.1080/13651500601127172 10.1038/jid.2013.446 10.3390/jcm11216269 10.1590/abd1806-4841.201533726 10.1001/jamadermatol.2022.2260 10.1016/j.jaad.2016.12.028 10.1186/s12895-018-0075-z 10.1016/j.jaad.2020.02.040 10.1001/jama.2021.17633 10.1111/bjd.13749 10.2340/00015555-3409 10.1111/jocd.14540 10.1038/mp.2015.197 10.4103/0019-5154.74539 10.1111/jocd.12294 10.2340/00015555-1598 10.1111/jocd.12708 10.2340/00015555-3636 10.1111/bjd.16099 10.4088/JCP.10r05993 10.1038/s41588-021-00857-4 10.1111/jdv.13191 10.1080/09546634.2017.1364693 10.1136/bmjopen-2018-021549 10.1038/s41586-022-04434-5 10.1155/2014/504279 |
| ContentType | Journal Article |
| Copyright | Copyright © 2023 Liu, Xue, Chen, Chen, Zhong, Shao and Chen. Copyright © 2023 Liu, Xue, Chen, Chen, Zhong, Shao and Chen. 2023 Liu, Xue, Chen, Chen, Zhong, Shao and Chen |
| Copyright_xml | – notice: Copyright © 2023 Liu, Xue, Chen, Chen, Zhong, Shao and Chen. – notice: Copyright © 2023 Liu, Xue, Chen, Chen, Zhong, Shao and Chen. 2023 Liu, Xue, Chen, Chen, Zhong, Shao and Chen |
| DBID | AAYXX CITATION CGR CUY CVF ECM EIF NPM 7X8 5PM DOA |
| DOI | 10.3389/fpubh.2023.1156522 |
| DatabaseName | CrossRef Medline MEDLINE MEDLINE (Ovid) MEDLINE MEDLINE PubMed MEDLINE - Academic PubMed Central (Full Participant titles) DOAJ Directory of Open Access Journals |
| DatabaseTitle | CrossRef MEDLINE Medline Complete MEDLINE with Full Text PubMed MEDLINE (Ovid) MEDLINE - Academic |
| DatabaseTitleList | MEDLINE MEDLINE - Academic |
| Database_xml | – sequence: 1 dbid: DOA name: DOAJ url: https://www.doaj.org/ sourceTypes: Open Website – sequence: 2 dbid: NPM name: PubMed url: http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?db=PubMed sourceTypes: Index Database – sequence: 3 dbid: 7X8 name: MEDLINE - Academic url: https://search.proquest.com/medline sourceTypes: Aggregation Database |
| DeliveryMethod | fulltext_linktorsrc |
| Discipline | Public Health |
| EISSN | 2296-2565 |
| ExternalDocumentID | oai_doaj_org_article_a7f6ed5a39524e3fa328573b75886a34 PMC10102334 37064666 10_3389_fpubh_2023_1156522 |
| Genre | Research Support, Non-U.S. Gov't Journal Article |
| GrantInformation_xml | – fundername: ; grantid: n82073462 |
| GroupedDBID | 53G 5VS 9T4 AAFWJ AAYXX ACGFO ACGFS ADBBV ADRAZ AFPKN ALMA_UNASSIGNED_HOLDINGS AOIJS BAWUL BCNDV CITATION DIK EMOBN GROUPED_DOAJ GX1 HYE KQ8 M48 M~E OK1 RNS RPM 2XV ACXDI CGR CUY CVF ECM EIF IAO IEA IHR IHW IOV IPNFZ NPM PGMZT RIG 7X8 5PM |
| ID | FETCH-LOGICAL-c469t-bd8ebd56195598c993c3246bd2c28fa033359c711cda9518215753d5f5e1320c3 |
| IEDL.DBID | DOA |
| ISICitedReferencesCount | 9 |
| ISICitedReferencesURI | http://www.webofscience.com/api/gateway?GWVersion=2&SrcApp=Summon&SrcAuth=ProQuest&DestLinkType=CitingArticles&DestApp=WOS_CPL&KeyUT=000968300400001&url=https%3A%2F%2Fcvtisr.summon.serialssolutions.com%2F%23%21%2Fsearch%3Fho%3Df%26include.ft.matches%3Dt%26l%3Dnull%26q%3D |
| ISSN | 2296-2565 |
| IngestDate | Fri Oct 03 12:50:49 EDT 2025 Thu Aug 21 18:38:04 EDT 2025 Fri Sep 05 11:56:31 EDT 2025 Thu Jan 02 22:53:11 EST 2025 Sat Nov 29 03:32:25 EST 2025 Tue Nov 18 22:29:43 EST 2025 |
| IsDoiOpenAccess | true |
| IsOpenAccess | true |
| IsPeerReviewed | true |
| IsScholarly | true |
| Keywords | GWAS Mendelian randomization schizophrenia acne mental disorders |
| Language | English |
| License | Copyright © 2023 Liu, Xue, Chen, Chen, Zhong, Shao and Chen. This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms. |
| LinkModel | DirectLink |
| MergedId | FETCHMERGED-LOGICAL-c469t-bd8ebd56195598c993c3246bd2c28fa033359c711cda9518215753d5f5e1320c3 |
| Notes | ObjectType-Article-1 SourceType-Scholarly Journals-1 ObjectType-Feature-2 content type line 23 Edited by: Hernan Cortes, National Institute of Rehabilitation Luis Guillermo Ibarra Ibarra, Mexico Reviewed by: Mohammed Abu El-Hamd, Sohag University, Egypt; Chiara Moltrasio, IRCCS Ca 'Granda Foundation Maggiore Policlinico Hospital, Italy; Karolina Chilicka-Hebel, Opole University, Poland This article was submitted to Public Mental Health, a section of the journal Frontiers in Public Health |
| OpenAccessLink | https://doaj.org/article/a7f6ed5a39524e3fa328573b75886a34 |
| PMID | 37064666 |
| PQID | 2802427065 |
| PQPubID | 23479 |
| ParticipantIDs | doaj_primary_oai_doaj_org_article_a7f6ed5a39524e3fa328573b75886a34 pubmedcentral_primary_oai_pubmedcentral_nih_gov_10102334 proquest_miscellaneous_2802427065 pubmed_primary_37064666 crossref_citationtrail_10_3389_fpubh_2023_1156522 crossref_primary_10_3389_fpubh_2023_1156522 |
| PublicationCentury | 2000 |
| PublicationDate | 2023-03-31 |
| PublicationDateYYYYMMDD | 2023-03-31 |
| PublicationDate_xml | – month: 03 year: 2023 text: 2023-03-31 day: 31 |
| PublicationDecade | 2020 |
| PublicationPlace | Switzerland |
| PublicationPlace_xml | – name: Switzerland |
| PublicationTitle | Frontiers in public health |
| PublicationTitleAlternate | Front Public Health |
| PublicationYear | 2023 |
| Publisher | Frontiers Media S.A |
| Publisher_xml | – name: Frontiers Media S.A |
| References | Vallerand (ref6) 2018; 178 Bez (ref9) 2013; 93 Sagaltici (ref21) 2021; 20 Howard (ref14) 2019; 22 Singh (ref30) 2021; 20 Dreno (ref29) 2018; 16 Revol (ref2) 2015; 172 Gieler (ref36) 2015; 29 Trubetskoy (ref16) 2022; 604 Vilar (ref34) 2015; 90 Kridin (ref10) 2022; 88 Hay (ref1) 2014; 134 Ludot (ref23) 2015; 5 Anzengruber (ref20) 2018; 29 Mullins (ref17) 2021; 53 Afkham Ebrahimi (ref19) 2007; 11 Davey Smith (ref12) 2014; 23 Yang (ref18) 2014; 2014 Tan (ref27) 2015; 172 Saka (ref32) 2018; 18 Eichenfield (ref28) 2021; 326 Bremner (ref22) 2012; 73 Gokalp (ref31) 2017; 16 Hopkins (ref33) 2022; 158 Mitchell (ref13) 2022; 13 Golchai (ref7) 2010; 55 Erdoğan (ref26) 2019; 21 Metekoglu (ref25) 2019; 32 Huang (ref11) 2017; 76 Otowa (ref15) 2016; 21 Martínez-García (ref35) 2020; 100 Özyay Eroğlu (ref8) 2019; 18 Li (ref24) 2019; 9 Chilicka (ref4) 2022; 11 Samuels (ref5) 2020; 83 Altunay (ref3) 2020; 100 |
| References_xml | – volume: 32 start-page: e12795 year: 2019 ident: ref25 article-title: Does isotretinoin cause depression and anxiety in acne patients? publication-title: Dermatol Ther doi: 10.1111/dth.12795 – volume: 13 start-page: 702 year: 2022 ident: ref13 article-title: Genome-wide association meta-analysis identifies 29 new acne susceptibility loci publication-title: Nat Commun doi: 10.1038/s41467-022-28252-5 – volume: 22 start-page: 343 year: 2019 ident: ref14 article-title: Genome-wide meta-analysis of depression identifies 102 independent variants and highlights the importance of the prefrontal brain regions publication-title: Nat Neurosci doi: 10.1038/s41593-018-0326-7 – volume: 172 start-page: 3 year: 2015 ident: ref27 article-title: A global perspective on the epidemiology of acne publication-title: Br J Dermatol doi: 10.1111/bjd.13462 – volume: 23 start-page: R89 year: 2014 ident: ref12 article-title: Mendelian randomization: genetic anchors for causal inference in epidemiological studies publication-title: Hum Mol Genet doi: 10.1093/hmg/ddu328 – volume: 16 start-page: 1185 year: 2018 ident: ref29 article-title: Female type of adult acne: physiological and psychological considerations and management. Journal der Deutschen Dermatologischen Gesellschaft = publication-title: J German Soc Dermatol JDDG doi: 10.1111/ddg.13664 – volume: 21 start-page: 195 year: 2019 ident: ref26 article-title: Comparison of quality of life, depression, anxiety, suicide, social anxiety and obsessive-compulsive symptoms between adolescents with acne receiving isotretinoin and antibiotics: a prospective, non-randomised, open-label study publication-title: Paediatr Drugs doi: 10.1007/s40272-019-00340-y – volume: 5 start-page: 222 year: 2015 ident: ref23 article-title: Inter-relationships between isotretinoin treatment and psychiatric disorders: depression, bipolar disorder, anxiety, psychosis and suicide risks publication-title: World J Psychiatr doi: 10.5498/wjp.v5.i2.222 – volume: 20 start-page: 3739 year: 2021 ident: ref21 article-title: Mental health and psychological resilience among acne vulgaris patients during the pandemic: a cross-sectional controlled study publication-title: J Cosmet Dermatol doi: 10.1111/jocd.14531 – volume: 88 start-page: 388 year: 2022 ident: ref10 article-title: Isotretinoin and the risk of psychiatric disturbances—a global study shedding new Light on a debatable story publication-title: J Am Acad Dermatol doi: 10.1016/j.jaad.2022.10.031 – volume: 11 start-page: 218 year: 2007 ident: ref19 article-title: Obsessive-compulsive disorder in dermatology outpatients publication-title: Int J Psychiatry Clin Pract doi: 10.1080/13651500601127172 – volume: 134 start-page: 1527 year: 2014 ident: ref1 article-title: The global burden of skin disease in 2010: an analysis of the prevalence and impact of skin conditions publication-title: J Invest Dermatol doi: 10.1038/jid.2013.446 – volume: 11 start-page: 6269 year: 2022 ident: ref4 article-title: Efficacy of hydrogen purification and cosmetic acids in the treatment of acne vulgaris: a preliminary report publication-title: J Clin Med doi: 10.3390/jcm11216269 – volume: 90 start-page: 622 year: 2015 ident: ref34 article-title: Quality of life, self-esteem and psychosocial factors in adolescents with acne vulgaris publication-title: An Bras Dermatol doi: 10.1590/abd1806-4841.201533726 – volume: 158 start-page: 900 year: 2022 ident: ref33 article-title: Patient-reported outcome measures for health-related quality of life in patients with acne vulgaris: a systematic review of measure development and measurement properties publication-title: JAMA Dermatol doi: 10.1001/jamadermatol.2022.2260 – volume: 76 start-page: 1068 year: 2017 ident: ref11 article-title: Isotretinoin treatment for acne and risk of depression: a systematic review and meta-analysis publication-title: J Am Acad Dermatol doi: 10.1016/j.jaad.2016.12.028 – volume: 18 start-page: 7 year: 2018 ident: ref32 article-title: Acne in Lomé, Togo: clinical aspects and quality of life of patients publication-title: BMC Dermatol doi: 10.1186/s12895-018-0075-z – volume: 83 start-page: 532 year: 2020 ident: ref5 article-title: Acne vulgaris and risk of depression and anxiety: a meta-analytic review publication-title: J Am Acad Dermatol doi: 10.1016/j.jaad.2020.02.040 – volume: 326 start-page: 2055 year: 2021 ident: ref28 article-title: Management of Acne Vulgaris: a review publication-title: JAMA doi: 10.1001/jama.2021.17633 – volume: 172 start-page: 52 year: 2015 ident: ref2 article-title: Psychological impact of acne on 21st-century adolescents: decoding for better care publication-title: Br J Dermatol doi: 10.1111/bjd.13749 – volume: 100 start-page: 01 year: 2020 ident: ref3 article-title: Psychosocial aspects of adult acne: data from 13 European countries publication-title: Acta Derm Venereol doi: 10.2340/00015555-3409 – volume: 20 start-page: 4017 year: 2021 ident: ref30 article-title: Quality of life in Young adults with acne: results of a cross-sectional study publication-title: J Cosmet Dermatol doi: 10.1111/jocd.14540 – volume: 21 start-page: 1391 year: 2016 ident: ref15 article-title: Meta-analysis of genome-wide association studies of anxiety disorders publication-title: Mol Psychiatry doi: 10.1038/mp.2015.197 – volume: 55 start-page: 352 year: 2010 ident: ref7 article-title: Comparison of anxiety and depression in patients with acne vulgaris and healthy individuals publication-title: Indian J Dermatol doi: 10.4103/0019-5154.74539 – volume: 16 start-page: 485 year: 2017 ident: ref31 article-title: Evaluation of the effects of acne vulgaris on quality of life in Turkey by using Taqli publication-title: J Cosmet Dermatol doi: 10.1111/jocd.12294 – volume: 93 start-page: 679 year: 2013 ident: ref9 article-title: Predictive value of obsessive compulsive symptoms involving the skin on quality of life in patients with acne vulgaris publication-title: Acta Derm Venereol doi: 10.2340/00015555-1598 – volume: 18 start-page: 916 year: 2019 ident: ref8 article-title: The evaluation of psychiatric comorbidity, self-injurious behavior, suicide probability, and other associated psychiatric factors (Lonileness, self-esteem, life satisfaction) in adolescents with acne: a clinical pilot study publication-title: J Cosmet Dermatol doi: 10.1111/jocd.12708 – volume: 100 start-page: adv00290 year: 2020 ident: ref35 article-title: Quality of life of cohabitants of people living with acne publication-title: Acta Derm Venereol doi: 10.2340/00015555-3636 – volume: 178 start-page: e194 year: 2018 ident: ref6 article-title: Risk of depression among patients with acne in the U.K.: a population-based cohort study publication-title: Br J Dermatol doi: 10.1111/bjd.16099 – volume: 73 start-page: 37 year: 2012 ident: ref22 article-title: Retinoic acid and affective disorders: the evidence for an association publication-title: J Clin Psychiatry doi: 10.4088/JCP.10r05993 – volume: 53 start-page: 817 year: 2021 ident: ref17 article-title: Genome-wide association study of more than 40,000 bipolar disorder cases provides new insights into the underlying biology publication-title: Nat Genet doi: 10.1038/s41588-021-00857-4 – volume: 29 start-page: 12 year: 2015 ident: ref36 article-title: Acne and quality of life—impact and management publication-title: J Eur Acad Dermatol Venereol doi: 10.1111/jdv.13191 – volume: 29 start-page: 277 year: 2018 ident: ref20 article-title: Wide range of age of onset and low referral rates to psychiatry in a large cohort of acne Excoriée at a Swiss tertiary hospital publication-title: J Dermatolog Treat doi: 10.1080/09546634.2017.1364693 – volume: 9 start-page: e021549 year: 2019 ident: ref24 article-title: Use of isotretinoin and risk of depression in patients with acne: a systematic review and meta-analysis publication-title: BMJ Open doi: 10.1136/bmjopen-2018-021549 – volume: 604 start-page: 502 year: 2022 ident: ref16 article-title: Mapping genomic loci implicates genes and synaptic biology in schizophrenia publication-title: Nature doi: 10.1038/s41586-022-04434-5 – volume: 2014 start-page: 1 year: 2014 ident: ref18 article-title: Female gender and acne disease are jointly and independently associated with ‑the risk of major depression and suicide: a National Population-Based Study publication-title: Biomed Res Int doi: 10.1155/2014/504279 |
| SSID | ssj0001034021 |
| Score | 2.2804408 |
| Snippet | Despite a growing body of evidence that acne impacts mental disorders, the actual causality has not been established for the possible presence of recall bias... BackgroundDespite a growing body of evidence that acne impacts mental disorders, the actual causality has not been established for the possible presence of... |
| SourceID | doaj pubmedcentral proquest pubmed crossref |
| SourceType | Open Website Open Access Repository Aggregation Database Index Database Enrichment Source |
| StartPage | 1156522 |
| SubjectTerms | acne Acne Vulgaris - epidemiology Acne Vulgaris - genetics Anxiety Disorders - epidemiology Genome-Wide Association Study GWAS Humans Mendelian randomization Mendelian Randomization Analysis mental disorders Public Health schizophrenia Stress Disorders, Post-Traumatic - epidemiology Stress Disorders, Post-Traumatic - genetics |
| Title | Acne and risk of mental disorders: A two-sample Mendelian randomization study based on large genome-wide association data |
| URI | https://www.ncbi.nlm.nih.gov/pubmed/37064666 https://www.proquest.com/docview/2802427065 https://pubmed.ncbi.nlm.nih.gov/PMC10102334 https://doaj.org/article/a7f6ed5a39524e3fa328573b75886a34 |
| Volume | 11 |
| WOSCitedRecordID | wos000968300400001&url=https%3A%2F%2Fcvtisr.summon.serialssolutions.com%2F%23%21%2Fsearch%3Fho%3Df%26include.ft.matches%3Dt%26l%3Dnull%26q%3D |
| hasFullText | 1 |
| inHoldings | 1 |
| isFullTextHit | |
| isPrint | |
| journalDatabaseRights | – providerCode: PRVAON databaseName: DOAJ customDbUrl: eissn: 2296-2565 dateEnd: 99991231 omitProxy: false ssIdentifier: ssj0001034021 issn: 2296-2565 databaseCode: DOA dateStart: 20130101 isFulltext: true titleUrlDefault: https://www.doaj.org/ providerName: Directory of Open Access Journals – providerCode: PRVHPJ databaseName: ROAD: Directory of Open Access Scholarly Resources (ISSN International Center) customDbUrl: eissn: 2296-2565 dateEnd: 99991231 omitProxy: false ssIdentifier: ssj0001034021 issn: 2296-2565 databaseCode: M~E dateStart: 20130101 isFulltext: true titleUrlDefault: https://road.issn.org providerName: ISSN International Centre |
| link | http://cvtisr.summon.serialssolutions.com/2.0.0/link/0/eLvHCXMwrV1Lb9QwELag4oCEqvIOj8pI3JDV2I4Th9sWteJAKw6A9mb5KVZqE9TdtuLCb2fGTpddhODCJVIcR7Y8Y_ub8cxnQl4719QWVkTmuVSsscox2yfOrOaNiwIMhMxb8OVDd3qq5_P-48ZVXxgTVuiBy8Ad2C61MSgreyWaKJOVQqtOOsC5urUyM4HWXb9hTGXvSi3BMOIlSwassP4A063w8EFIWCUAxQixtRNlwv4_oczfgyU3dp_jPbI7wUY6K929T27F4QG5V3xutKQSPSTfZ36I1A6BYsA4HRMtzP00TBSby7d0RlfXI1taJAWmJ-j_Rj8HhR0rjOdTTibNnLMUN7hA4fUMo8UpsrmeR3a9CNDGL6FSjDF9RD4fH316955NVyswD_bwirmgowuAnZCATnsAKR6QVeuC8EInW0spVe87zn2wgME0AAOwa4JKKmLOtZePyc4wDvEpoYm3rfaplj4B9nLBKStskNEizQ6gp4rwm2E2fuIdx-svzgzYHygak0VjUDRmEk1F3qz_-VZYN_5a-xClt66JjNm5APTITHpk_qVHFXl1I3sDMwyPTewQx8ulERpxDB4HV-RJ0YV1UxKKG7AAK6K3tGSrL9tfhsXXzOLNkc1PyubZ_-j9c3IXR6QkS74gO6uLy_iS3PFXq8XyYp_c7uZ6P88QeJ78OPoJYpAVzg |
| linkProvider | Directory of Open Access Journals |
| openUrl | ctx_ver=Z39.88-2004&ctx_enc=info%3Aofi%2Fenc%3AUTF-8&rfr_id=info%3Asid%2Fsummon.serialssolutions.com&rft_val_fmt=info%3Aofi%2Ffmt%3Akev%3Amtx%3Ajournal&rft.genre=article&rft.atitle=Acne+and+risk+of+mental+disorders%3A+A+two-sample+Mendelian+randomization+study+based+on+large+genome-wide+association+data&rft.jtitle=Frontiers+in+public+health&rft.au=Liu%2C+Lin&rft.au=Xue%2C+Yuzhou&rft.au=Chen%2C+Yangmei&rft.au=Chen%2C+Tingqiao&rft.date=2023-03-31&rft.pub=Frontiers+Media+S.A&rft.eissn=2296-2565&rft.volume=11&rft_id=info:doi/10.3389%2Ffpubh.2023.1156522&rft.externalDocID=PMC10102334 |
| thumbnail_l | http://covers-cdn.summon.serialssolutions.com/index.aspx?isbn=/lc.gif&issn=2296-2565&client=summon |
| thumbnail_m | http://covers-cdn.summon.serialssolutions.com/index.aspx?isbn=/mc.gif&issn=2296-2565&client=summon |
| thumbnail_s | http://covers-cdn.summon.serialssolutions.com/index.aspx?isbn=/sc.gif&issn=2296-2565&client=summon |