Acne and risk of mental disorders: A two-sample Mendelian randomization study based on large genome-wide association data

Despite a growing body of evidence that acne impacts mental disorders, the actual causality has not been established for the possible presence of recall bias and confounders in observational studies. We performed a two-sample Mendelian randomization (MR) analysis to evaluate the effect of acne on th...

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Vydáno v:	Frontiers in public health Ročník 11; s. 1156522
Hlavní autoři:	Liu, Lin, Xue, Yuzhou, Chen, Yangmei, Chen, Tingqiao, Zhong, Judan, Shao, Xinyi, Chen, Jin
Médium:	Journal Article
Jazyk:	angličtina
Vydáno:	Switzerland Frontiers Media S.A 31.03.2023
Témata:	acne Acne Vulgaris - epidemiology Acne Vulgaris - genetics Anxiety Disorders - epidemiology Genome-Wide Association Study GWAS Humans Mendelian randomization Mendelian Randomization Analysis mental disorders Public Health schizophrenia Stress Disorders, Post-Traumatic - epidemiology Stress Disorders, Post-Traumatic - genetics GWAS Mendelian randomization schizophrenia acne mental disorders
ISSN:	2296-2565, 2296-2565
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Shrnutí:	Despite a growing body of evidence that acne impacts mental disorders, the actual causality has not been established for the possible presence of recall bias and confounders in observational studies. We performed a two-sample Mendelian randomization (MR) analysis to evaluate the effect of acne on the risk of six common mental disorders, i.e., depression, anxiety, schizophrenia, obsessive-compulsive disorder (OCD), bipolar disorder, and post-traumatic stress disorder (PTSD). We acquired genetic instruments for assessing acne from the largest genome-wide association study (GWAS) of acne ( = 615,396) and collected summary statistics from the largest available GWAS for depression ( = 500,199), anxiety ( = 17,310), schizophrenia ( = 130,644), OCD ( = 9,725), bipolar disorder ( = 413,466), and PTSD ( = 174,659). Next, we performed the two-sample MR analysis using four methods: inverse-variance weighted method, MR-Egger, weighted median, and MR pleiotropy residual sum and outliers. Sensitivity analysis was also performed for heterogeneity and pleiotropy tests. There was no evidence of a causal impact of acne on the risk of depression [odds ratio (OR): 1.002, = 0.874], anxiety (OR: 0.961, = 0.49), OCD (OR: 0.979, = 0.741), bipolar disorder (OR: 0.972, = 0.261), and PTSD (OR: 1.054, = 0.069). Moreover, a mild protective effect of acne against schizophrenia was observed (OR: 0.944; = 0.033). The increased prevalence of mental disorders observed in patients with acne in clinical practice was caused by modifiable factors, and was not a direct outcome of acne. Therefore, strategies targeting the elimination of potential factors and minimization of the occurrence of adverse mental events in acne should be implemented.
Bibliografie:	ObjectType-Article-1 SourceType-Scholarly Journals-1 ObjectType-Feature-2 content type line 23 Edited by: Hernan Cortes, National Institute of Rehabilitation Luis Guillermo Ibarra Ibarra, Mexico Reviewed by: Mohammed Abu El-Hamd, Sohag University, Egypt; Chiara Moltrasio, IRCCS Ca 'Granda Foundation Maggiore Policlinico Hospital, Italy; Karolina Chilicka-Hebel, Opole University, Poland This article was submitted to Public Mental Health, a section of the journal Frontiers in Public Health
ISSN:	2296-2565 2296-2565
DOI:	10.3389/fpubh.2023.1156522