An Electrochemical Molecularly Imprinted Polymer Sensor for Rapid β-Lactoglobulin Detection

Facile detection of β-lactoglobulin is extraordinarily important for the management of the allergenic safety of cow’s milk and its dairy products. A sensitive electrochemical sensor based on a molecularly imprinted polymer-modified carbon electrode for the detection of β-lactoglobulin was successful...

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Bibliographic Details
Published in:Sensors (Basel, Switzerland) Vol. 21; no. 24; p. 8240
Main Authors: Wang, Bixuan, Hong, Jingyi, Liu, Chun, Zhu, Liying, Jiang, Ling
Format: Journal Article
Language:English
Published: Switzerland MDPI AG 09.12.2021
MDPI
Subjects:
Allergens
Allergies
Carbon
Composite materials
Dairy products
electrochemical sensor
Electrochemical Techniques
Electrodes
Fourier transforms
Graphene
Lactoglobulins
Limit of Detection
Medical research
Milk
Molecular Imprinting
molecularly imprinted polymer
Molecularly Imprinted Polymers
Polymers
Proteins
screen-printed carbon electrode
Sensors
Spectrum analysis
Voltammetry
β-lactoglobulin
United States > US
China
Japan
molecularly imprinted polymer
electrochemical sensor
screen-printed carbon electrode
β-lactoglobulin
ISSN:1424-8220, 1424-8220
Online Access:Get full text
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Summary:Facile detection of β-lactoglobulin is extraordinarily important for the management of the allergenic safety of cow’s milk and its dairy products. A sensitive electrochemical sensor based on a molecularly imprinted polymer-modified carbon electrode for the detection of β-lactoglobulin was successfully synthesized. This molecularly imprinted polymer was prepared using a hydrothermal method with choline chloride as a functional monomer, β-lactoglobulin as template molecule and ethylene glycol dimethacrylate as crosslinking agent. Then, the molecularly imprinted polymer was immobilized on polyethyleneimine (PEI)-reduced graphene oxide (rGO)-gold nanoclusters (Au-NCs) to improve the sensor’s selectivity for β-lactoglobulin. Under optimal experimental conditions, the designed sensor showed a good response to β-lactoglobulin, with a linear detection range between 10−9 and 10−4 mg/mL, and a detection limit of 10−9 mg/mL (S/N = 3). The developed electrochemical sensor showed a high correlation in the detection of β-lactoglobulin in four different milk samples from the market, indicating that the sensor can be used with actual sample.
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These authors contributed equally to this work.
ISSN:1424-8220
1424-8220
DOI:10.3390/s21248240