Deconstructing the Phage–Bacterial Biofilm Interaction as a Basis to Establish New Antibiofilm Strategies

The bacterial biofilm constitutes a complex environment that endows the bacterial community within with an ability to cope with biotic and abiotic stresses. Considering the interaction with bacterial viruses, these biofilms contain intrinsic defense mechanisms that protect against phage predation; t...

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Vydané v:	Viruses Ročník 14; číslo 5; s. 1057
Hlavní autori:	Visnapuu, Annegrete, Van der Gucht, Marie, Wagemans, Jeroen, Lavigne, Rob
Médium:	Journal Article
Jazyk:	English
Vydavateľské údaje:	Switzerland MDPI AG 16.05.2022 MDPI
Predmet:	Adsorption antibiofilm mechanism Bacteria Bacteria - genetics Bacterial infections bacterial–bacteriophage co-evolution Bacteriophages - genetics biofilm biofilm matrix protection mechanisms Biofilms Cell interactions Exopolysaccharides Extracellular matrix Gene expression Gene transfer Horizontal transfer Infections Metabolism Motility Peptidoglycans phage Phages Physiology Predation Predators predator–prey arms race Proteins Review Transplants & implants bacterial–bacteriophage co-evolution phage–host interaction biofilm biofilm matrix protection mechanisms predator–prey arms race antibiofilm mechanism phage
ISSN:	1999-4915, 1999-4915
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Shrnutí:	The bacterial biofilm constitutes a complex environment that endows the bacterial community within with an ability to cope with biotic and abiotic stresses. Considering the interaction with bacterial viruses, these biofilms contain intrinsic defense mechanisms that protect against phage predation; these mechanisms are driven by physical, structural, and metabolic properties or governed by environment-induced mutations and bacterial diversity. In this regard, horizontal gene transfer can also be a driver of biofilm diversity and some (pro)phages can function as temporary allies in biofilm development. Conversely, as bacterial predators, phages have developed counter mechanisms to overcome the biofilm barrier. We highlight how these natural systems have previously inspired new antibiofilm design strategies, e.g., by utilizing exopolysaccharide degrading enzymes and peptidoglycan hydrolases. Next, we propose new potential approaches including phage-encoded DNases to target extracellular DNA, as well as phage-mediated inhibitors of cellular communication; these examples illustrate the relevance and importance of research aiming to elucidate novel antibiofilm mechanisms contained within the vast set of unknown ORFs from phages.
Bibliografia:	ObjectType-Article-1 SourceType-Scholarly Journals-1 ObjectType-Feature-2 content type line 14 ObjectType-Review-3 content type line 23
ISSN:	1999-4915 1999-4915
DOI:	10.3390/v14051057