New insights into the mechanisms of diabetic complications: role of lipids and lipid metabolism

Diabetes adversely affects multiple organs, including the kidney, eye and nerve, leading to diabetic kidney disease, diabetic retinopathy and diabetic neuropathy, respectively. In both type 1 and type 2 diabetes, tissue damage is organ specific and is secondary to a combination of multiple metabolic...

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Vydané v:	Diabetologia Ročník 62; číslo 9; s. 1539 - 1549
Hlavní autori:	Eid, Stephanie, Sas, Kelli M., Abcouwer, Steven F., Feldman, Eva L., Gardner, Thomas W., Pennathur, Subramaniam, Fort, Patrice E.
Médium:	Journal Article
Jazyk:	English
Vydavateľské údaje:	Berlin/Heidelberg Springer Berlin Heidelberg 01.09.2019 Springer Nature B.V
Predmet:	Animals Bioenergetics Diabetes Diabetes mellitus Diabetes mellitus (insulin dependent) Diabetes mellitus (non-insulin dependent) Diabetes Mellitus, Type 1 - complications Diabetes Mellitus, Type 1 - metabolism Diabetes Mellitus, Type 2 - complications Diabetes Mellitus, Type 2 - metabolism Diabetic Neuropathies - metabolism Diabetic neuropathy Diabetic retinopathy Diabetic Retinopathy - metabolism Dyslipidemia Human Physiology Humans Hyperglycemia Internal Medicine Kidney diseases Lipid metabolism Lipid Metabolism - physiology Lipids Medicine Medicine & Public Health Metabolic Diseases Metabolism Metabolomics Retinopathy Review Specific mechanisms Diabetic complications Diabetes Lipid metabolism Review Omics
ISSN:	0012-186X, 1432-0428, 1432-0428
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Popis
Shrnutí:	Diabetes adversely affects multiple organs, including the kidney, eye and nerve, leading to diabetic kidney disease, diabetic retinopathy and diabetic neuropathy, respectively. In both type 1 and type 2 diabetes, tissue damage is organ specific and is secondary to a combination of multiple metabolic insults. Hyperglycaemia, dyslipidaemia and hypertension combine with the duration and type of diabetes to define the distinct pathophysiology underlying diabetic kidney disease, diabetic retinopathy and diabetic neuropathy. Only recently have the commonalities and differences in the metabolic basis of these tissue-specific complications, particularly those involving local and systemic lipids, been systematically examined. This review focuses on recent progress made using preclinical models and human-based approaches towards understanding how bioenergetics and metabolomic profiles contribute to diabetic kidney disease, diabetic retinopathy and diabetic neuropathy. This new understanding of the biology of complication-prone tissues highlights the need for organ-specific interventions in the treatment of diabetic complications.
Bibliografia:	ObjectType-Article-1 SourceType-Scholarly Journals-1 ObjectType-Feature-2 content type line 14 ObjectType-Literature Review-3 ObjectType-Review-3 content type line 23 Contribution statement All authors were responsible for drafting the article and revising it critically for important intellectual content. All authors approved the version to be published.
ISSN:	0012-186X 1432-0428 1432-0428
DOI:	10.1007/s00125-019-4959-1