Maternal high-intensity interval training as a suitable approach for offspring’s heart protection in rat: evidence from oxidative stress and mitochondrial genes

Considerable scientific evidence suggests that the intrauterine environment plays a crucial role in determining the long-term health of offspring. The present study aims to investigate the effects of high-intensity interval training in maternal rats before and during pregnancy on the antioxidant sta...

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Vydané v:Frontiers in physiology Ročník 14; s. 1117666
Hlavní autori: Mohammadkhani, Reihaneh, Komaki, Alireza, Karimi, Seyed Asaad, Behzad, Mahdi, Heidarisasan, Shirin, Salehi, Iraj
Médium: Journal Article
Jazyk:English
Vydavateľské údaje: Switzerland Frontiers Media S.A 23.05.2023
Predmet:
elevated plus-maze
high-intensity interval training
maternal exercise
mitochondrial gene expression
offspring
oxidant-antioxidant status
Physiology
elevated plus-maze
high-intensity interval training
offspring
open-field
mitochondrial gene expression
oxidant-antioxidant status
maternal exercise
ISSN:1664-042X, 1664-042X
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Shrnutí:Considerable scientific evidence suggests that the intrauterine environment plays a crucial role in determining the long-term health of offspring. The present study aims to investigate the effects of high-intensity interval training in maternal rats before and during pregnancy on the antioxidant status, mitochondrial gene expression, and anxiety-like behavior of their offspring. A total of thirty-two female rats were assigned to four maternal groups based on the timing of exercise: before pregnancy, before and during pregnancy, during pregnancy, and sedentary. The female and male offspring were allocated to groups that matched their mothers’ exercise regimen. Anxiety-like behavior in the offspring was evaluated using the open-field and elevated plus-maze tests. Our findings indicate that maternal HIIT does not have any detrimental effect on the anxiety-related behavior of offspring. Also, maternal exercise before and during pregnancy could improve the general activity of the offspring. Furthermore, our results demonstrate that female offspring exhibit more locomotion activity than males. Besides, maternal HIIT leads to a reduction in the levels of TOS and MDA, while TAC levels increase, and significantly upregulate the gene expression of PGC1-α, NFR1, and NRF2 in both sexes in the heart. Therefore, our study suggests that maternal HIIT is a beneficial maternal behavior and serves as a cardioprotective agent to enhance the health of the next generations.
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Reviewed by: Laura Reck Cechinel, Children’s National Hospital, United States
Edited by: Angela Di Baldassarre, University of Studies G. d’Annunzio Chieti and Pescara, Italy
Silvia Lores Arnaiz, University of Buenos Aires, Argentina
ISSN:1664-042X
1664-042X
DOI:10.3389/fphys.2023.1117666