Physiochemical properties and application of hyaluronic acid: a systematic review

Summary Background Hyaluronic acid is a widely available, biocompatible, polysaccharide with distinguishing physiochemical properties which inspire its application throughout several fields of medicine. Objective We aim to investigate the application of hyaluronic acid and its effectiveness througho...

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Vydané v:Journal of cosmetic dermatology Ročník 15; číslo 4; s. 520 - 526
Hlavní autori: Salwowska, Natalia M, Bebenek, Katarzyna A, Żądło, Dominika A, Wcisło-Dziadecka, Dominika L
Médium: Journal Article
Jazyk:English
Vydavateľské údaje: England Blackwell Publishing Ltd 01.12.2016
Predmet:
adjuvant therapy
bioavailability
Biological Availability
Cosmetic Techniques
Dermal Fillers - adverse effects
Dermal Fillers - pharmacokinetics
Dermal Fillers - therapeutic use
Dry Eye Syndromes - drug therapy
Humans
hyaluronic acid
Hyaluronic Acid - adverse effects
Hyaluronic Acid - metabolism
Hyaluronic Acid - pharmacokinetics
Hyaluronic Acid - therapeutic use
long-lasting effect
Neoplasms - metabolism
Osteoarthritis - drug therapy
Randomized Controlled Trials as Topic
tolerability
Viscosupplements - adverse effects
Viscosupplements - pharmacokinetics
Viscosupplements - therapeutic use
wound healing
adjuvant therapy
long-lasting effect
wound healing
bioavailability
tolerability
hyaluronic acid
ISSN:1473-2130, 1473-2165, 1473-2165
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Shrnutí:Summary Background Hyaluronic acid is a widely available, biocompatible, polysaccharide with distinguishing physiochemical properties which inspire its application throughout several fields of medicine. Objective We aim to investigate the application of hyaluronic acid and its effectiveness throughout several fields of medicine, including several therapies administered and prescribed by general health practitioners. Methods We conducted a systematic review on randomized controlled trials about the physiochemical properties of hyaluronic acid and its application through primary care. Studies included in this review were peer reviewed and met our inclusion criteria. Findings Factors were clustered into the following: uses throughout several fields of medicine, physiochemical properties, bioavailability, tolerance, effectiveness, and adverse effects. Therapies with hyaluronic acid provided long‐lasting, pain relieving, moisturizing, lubricating, and dermal filling effect. Tissue hydration, elasticity, and durability improved. Conclusions Adjunct therapy with hyaluronic acid provides longer‐lasting therapeutic effect when compared to the use of glucocorticosteroids and NSAIDs in osteoarthritic chronic diseases, is well‐established in ophthalmology due to its lubricating properties for the corneal endothelium, and improves tissue hydration and cellular resistance to mechanical damage in aesthetic dermatology, and has marginal adverse effects. Several trials indicated its role in tumor markers, liver diseases, and in pharmaceuticals, but further research would be necessary to draw conclusive results in those fields.
Bibliografia:ark:/67375/WNG-9THWH5X1-7
istex:853A68209957BEF0B256EFB87C318675C3D3B4E9
ArticleID:JOCD12237
ObjectType-Article-1
SourceType-Scholarly Journals-1
ObjectType-Feature-2
ObjectType-Review-3
content type line 23
ObjectType-Undefined-4
ISSN:1473-2130
1473-2165
1473-2165
DOI:10.1111/jocd.12237