Pregnancy and antibody-mediated CNS disorders: What do we know and what should we know?

Antibody-mediated central nervous system (CNS) disorders including those associated with aquaporin-4 or myelin oligodendrocyte glycoprotein IgG and autoimmune encephalitis often affect women of childbearing age. Pathogenic antibodies of these diseases can potentially alter reproductive functions and...

Full description

Saved in:
Bibliographic Details
Published in:Frontiers in neurology Vol. 13; p. 1048502
Main Authors: Cortese, Rosa, Mariotto, Sara, Mancinelli, Chiara Rosa, Tortorella, Carla
Format: Journal Article
Language:English
Published: Switzerland Frontiers Media S.A 19.12.2022
Subjects:
autoimmune encephalitis
breastfeeding
myelin oligodendrocyte (MOG) antibody associated disease
Neurology
neuromyelitis optica spectrum disorders (not in MeSH)
postpartum
pregnancy
autoimmune encephalitis
postpartum
breastfeeding
neuromyelitis optica spectrum disorders (not in MeSH)
myelin oligodendrocyte (MOG) antibody associated disease
pregnancy
ISSN:1664-2295, 1664-2295
Online Access:Get full text
Tags: Add Tag
No Tags, Be the first to tag this record!
Description
Summary:Antibody-mediated central nervous system (CNS) disorders including those associated with aquaporin-4 or myelin oligodendrocyte glycoprotein IgG and autoimmune encephalitis often affect women of childbearing age. Pathogenic antibodies of these diseases can potentially alter reproductive functions and influence fetal development. Hormonal changes occurring during pregnancy may modify the course of autoimmune diseases by influencing relapse risk, attack severity, and affect the delivery and postpartum period. Moreover, balancing treatment related safety issues with the risk of potentially disabling relapses during pregnancy and breastfeeding are major challenges. Intentional prenatal, gestational, and post-partum counseling is paramount to address these issues and mitigate these risks. Fortunately, new insights on risk factors for adverse pregnancy outcomes and possible preventive strategies are emerging. This review aims to summarize the interplay between antibody-mediated CNS disorders and pregnancy during the prenatal, gestational, and postpartum periods, highlight current treatment recommendations, and discuss future areas of research.
Bibliography:ObjectType-Article-1
SourceType-Scholarly Journals-1
ObjectType-Feature-2
ObjectType-Review-3
content type line 23
Reviewed by: Rana Khalil Zabad, University of Nebraska Medical Center, United States; Jodie Burton, University of Calgary, Canada
This article was submitted to Multiple Sclerosis and Neuroimmunology, a section of the journal Frontiers in Neurology
Edited by: Antonia Ceccarelli, Centre Hospitalier EpiCURA/Free University of Brussels (UZ Brussel) VUB, Belgium
ISSN:1664-2295
1664-2295
DOI:10.3389/fneur.2022.1048502