Use of computational fluid dynamics deposition modeling in respiratory drug delivery

Introduction: Respiratory drug delivery is a surprisingly complex process with a number of physical and biological challenges. Computational fluid dynamics (CFD) is a scientific simulation technique that is capable of providing spatially and temporally resolved predictions of many aspects related to...

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Podrobná bibliografia
Vydané v:	Expert opinion on drug delivery Ročník 16; číslo 1; s. 7 - 26
Hlavní autori:	Longest, P. Worth, Bass, Karl, Dutta, Rabijit, Rani, Vijaya, Thomas, Morgan L., El-Achwah, Ahmad, Hindle, Michael
Médium:	Journal Article
Jazyk:	English
Vydavateľské údaje:	England Taylor & Francis 02.01.2019
Predmet:	Administration, Inhalation aerosol deposition aerosol dosimetry Aerosols - administration & dosage airway models Asthma - drug therapy bioequivalence CFD simulations complete-airway modeling Computer Simulation Drug Compounding Drug Delivery Systems - methods Humans Hydrodynamics inhalers Models, Biological Nebulizers and Vaporizers Pharmaceutical aerosols Therapeutic Equivalency whole-lung CFD modeling inhalers whole-lung CFD modeling aerosol deposition Pharmaceutical aerosols complete-airway modeling airway models CFD simulations aerosol dosimetry bioequivalence
ISSN:	1742-5247, 1744-7593, 1744-7593
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Popis
Shrnutí:	Introduction: Respiratory drug delivery is a surprisingly complex process with a number of physical and biological challenges. Computational fluid dynamics (CFD) is a scientific simulation technique that is capable of providing spatially and temporally resolved predictions of many aspects related to respiratory drug delivery from initial aerosol formation through respiratory cellular drug absorption. Areas covered: This review article focuses on CFD-based deposition modeling applied to pharmaceutical aerosols. Areas covered include the development of new complete-airway CFD deposition models and the application of these models to develop a next-generation of respiratory drug delivery strategies. Expert opinion: Complete-airway deposition modeling is a valuable research tool that can improve our understanding of pharmaceutical aerosol delivery and is already supporting medical hypotheses, such as the expected under-treatment of the small airways in asthma. These complete-airway models are also being used to advance next-generation aerosol delivery strategies, like controlled condensational growth. We envision future applications of CFD deposition modeling to reduce the need for human subject testing in developing new devices and formulations, to help establish bioequivalence for the accelerated approval of generic inhalers, and to provide valuable new insights related to drug dissolution and clearance leading to microdosimetry maps of drug absorption.
Bibliografia:	ObjectType-Article-1 SourceType-Scholarly Journals-1 ObjectType-Feature-2 ObjectType-Review-3 content type line 23
ISSN:	1742-5247 1744-7593 1744-7593
DOI:	10.1080/17425247.2019.1551875