Use of computational fluid dynamics deposition modeling in respiratory drug delivery

Introduction: Respiratory drug delivery is a surprisingly complex process with a number of physical and biological challenges. Computational fluid dynamics (CFD) is a scientific simulation technique that is capable of providing spatially and temporally resolved predictions of many aspects related to...

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Vydáno v:Expert opinion on drug delivery Ročník 16; číslo 1; s. 7 - 26
Hlavní autoři: Longest, P. Worth, Bass, Karl, Dutta, Rabijit, Rani, Vijaya, Thomas, Morgan L., El-Achwah, Ahmad, Hindle, Michael
Médium: Journal Article
Jazyk:angličtina
Vydáno: England Taylor & Francis 02.01.2019
Témata:
Administration, Inhalation
aerosol deposition
aerosol dosimetry
Aerosols - administration & dosage
airway models
Asthma - drug therapy
bioequivalence
CFD simulations
complete-airway modeling
Computer Simulation
Drug Compounding
Drug Delivery Systems - methods
Humans
Hydrodynamics
inhalers
Models, Biological
Nebulizers and Vaporizers
Pharmaceutical aerosols
Therapeutic Equivalency
whole-lung CFD modeling
inhalers
whole-lung CFD modeling
aerosol deposition
Pharmaceutical aerosols
complete-airway modeling
airway models
CFD simulations
aerosol dosimetry
bioequivalence
ISSN:1742-5247, 1744-7593, 1744-7593
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Shrnutí:Introduction: Respiratory drug delivery is a surprisingly complex process with a number of physical and biological challenges. Computational fluid dynamics (CFD) is a scientific simulation technique that is capable of providing spatially and temporally resolved predictions of many aspects related to respiratory drug delivery from initial aerosol formation through respiratory cellular drug absorption. Areas covered: This review article focuses on CFD-based deposition modeling applied to pharmaceutical aerosols. Areas covered include the development of new complete-airway CFD deposition models and the application of these models to develop a next-generation of respiratory drug delivery strategies. Expert opinion: Complete-airway deposition modeling is a valuable research tool that can improve our understanding of pharmaceutical aerosol delivery and is already supporting medical hypotheses, such as the expected under-treatment of the small airways in asthma. These complete-airway models are also being used to advance next-generation aerosol delivery strategies, like controlled condensational growth. We envision future applications of CFD deposition modeling to reduce the need for human subject testing in developing new devices and formulations, to help establish bioequivalence for the accelerated approval of generic inhalers, and to provide valuable new insights related to drug dissolution and clearance leading to microdosimetry maps of drug absorption.
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ISSN:1742-5247
1744-7593
1744-7593
DOI:10.1080/17425247.2019.1551875