Biodegradable Microsphere-Hydrogel Ocular Drug Delivery System for Controlled and Extended Release of Bioactive Aflibercept In Vitro

Purpose: Current standard of care for neovascular eye diseases require repeated intravitreal bolus injections of anti-vascular endothelial growth factors (anti-VEGFs). The purpose of this study was to validate a degradable microsphere-thermoresponsive hydrogel drug delivery system (DDS) capable of r...

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Bibliographic Details
Published in:	Current eye research Vol. 44; no. 3; pp. 264 - 274
Main Authors:	Liu, Wenqiang, Lee, Bao-Shiang, Mieler, William F., Kang-Mieler, Jennifer J.
Format:	Journal Article
Language:	English
Published:	England Taylor & Francis 04.03.2019
Subjects:	Absorbable Implants Acrylamides - chemistry Acrylates - chemistry Angiogenesis Inhibitors - administration & dosage Angiogenesis Inhibitors - pharmacokinetics Animals Anti-VEGF delivery bioactivity Cell Survival Cells, Cultured Delayed-Action Preparations Drug Delivery Systems Enzyme-Linked Immunosorbent Assay Human Umbilical Vein Endothelial Cells - drug effects Humans Hydrogels - chemistry Immunoblotting intravitreal injection Microspheres neovascularization Polyethylene Glycols - chemistry Receptors, Vascular Endothelial Growth Factor - administration & dosage Recombinant Fusion Proteins - administration & dosage Recombinant Fusion Proteins - pharmacokinetics thermoresponsive hydrogel Vascular Endothelial Growth Factor A - antagonists & inhibitors intravitreal injection bioactivity thermoresponsive hydrogel Anti-VEGF delivery neovascularization
ISSN:	0271-3683, 1460-2202, 1460-2202
Online Access:	Get full text
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