A novel method for real-time analysis of the complement C3b:FH:FI complex reveals dominant negative CFI variants in age-related macular degeneration

Age-related macular degeneration (AMD) is linked to 2 main disparate genetic pathways: a chromosome 10 risk locus and the alternative pathway (AP) of complement. Rare genetic variants in complement factor H ( CFH; FH ) and factor I ( CFI; FI ) are associated with AMD. FH acts as a soluble cofactor t...

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Bibliographic Details
Published in:	Frontiers in immunology Vol. 13; p. 1028760
Main Authors:	Hallam, Thomas M., Cox, Thomas E., Smith-Jackson, Kate, Brocklebank, Vicky, Baral, April J., Tzoumas, Nikolaos, Steel, David H., Wong, Edwin K. S., Shuttleworth, Victoria G., Lotery, Andrew J., Harris, Claire L., Marchbank, Kevin J., Kavanagh, David
Format:	Journal Article
Language:	English
Published:	Switzerland Frontiers Media S.A 28.12.2022
Subjects:	aHUS (atypical haemolytic uraemic syndrome) AMD (age-related macular degeneration) Complement Complement C3b - genetics Complement Factor H - genetics Complement Factor I - genetics Factor H Factor I Humans Immunology Macular Degeneration - genetics Surface plasmon resonance Factor H AMD (age-related macular degeneration) PNH (paroxysmal nocturnal haemoglobinuria) C3G (C3 Glomerulopathy) Complement Surface plasmon resonance aHUS (atypical haemolytic uraemic syndrome) Factor I
ISSN:	1664-3224, 1664-3224
Online Access:	Get full text
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