Regulation of H2A ubiquitination and SLC7A11 expression by BAP1 and PRC1

SLC7A11 (or xCT) imports extracellular cystine into cells to promote glutathione synthesis, thus inhibiting ferroptosis. SLC7A11 expression is tightly controlled in normal cells and its dysregulation results in aberrant expression of SLC7A11 in human cancers. We recently discovered that tumor suppre...

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Bibliographic Details
Published in:	Cell cycle (Georgetown, Tex.) Vol. 18; no. 8; pp. 773 - 783
Main Authors:	Zhang, Yilei, Koppula, Pranavi, Gan, Boyi
Format:	Journal Article
Language:	English
Published:	United States Taylor & Francis 18.04.2019
Subjects:	Activating Transcription Factor 4 - metabolism Amino Acid Transport System y+ - genetics Amino Acid Transport System y+ - metabolism BAP1 Cell Cycle Proteins - metabolism Cell Line, Tumor Cell Survival - drug effects Extra View ferroptosis Ferroptosis - drug effects Ferroptosis - genetics Gene Expression Regulation, Neoplastic Gene Knockdown Techniques H2A ubiquitination HEK293 Cells Histones - metabolism Humans Neoplasms - metabolism NF-E2-Related Factor 2 - metabolism Piperazines - pharmacology PRC1 Promoter Regions, Genetic SLC7A11 Transfection Tumor Suppressor Proteins - genetics Tumor Suppressor Proteins - metabolism Ubiquitin Thiolesterase - genetics Ubiquitin Thiolesterase - metabolism Ubiquitination H2A ubiquitination ferroptosis SLC7A11 PRC1 BAP1
ISSN:	1538-4101, 1551-4005, 1551-4005
Online Access:	Get full text
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