Application of an angiogenesis-related genes risk model in lung adenocarcinoma prognosis and immunotherapy

Lung adenocarcinoma (LUAD) is an essential pathological subtype of non-small cell lung cancer and offers a severe problem for worldwide public health. There is mounting proof that angiogenesis is a crucial player in LUAD progression. Consequently, the purpose of this research was to construct a nove...

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Veröffentlicht in:Frontiers in genetics Jg. 14; S. 1092968
Hauptverfasser: Wang, Jinsong, Cui, Xue, Weng, Yiming, Wei, Jiayan, Chen, Xinyi, Wang, Peiwei, Wang, Tong, Qin, Jian, Peng, Min
Format: Journal Article
Sprache:Englisch
Veröffentlicht: Switzerland Frontiers Media S.A 01.02.2023
Schlagworte:
angiogenesis-related genes
Genetics
immunotherapy
lung adenocarcinoma
prognosis
risk model
prognosis
angiogenesis-related genes
risk model
immunotherapy
lung adenocarcinoma
ISSN:1664-8021, 1664-8021
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Zusammenfassung:Lung adenocarcinoma (LUAD) is an essential pathological subtype of non-small cell lung cancer and offers a severe problem for worldwide public health. There is mounting proof that angiogenesis is a crucial player in LUAD progression. Consequently, the purpose of this research was to construct a novel LUAD risk assessment model based on genetic markers related to angiogenesis. We accessed The Cancer Genome Atlas (TCGA) and Gene Expression Omnibus (GEO) databases for LUAD mRNA sequencing data and clinical information. Based on machine algorithms and bioinformatics, angiogenic gene-related risk scores (RS) were calculated. Patients in the high-risk category had a worse prognosis ( p < 0.001) in the discovery TCGA cohort, and the results were confirmed by these three cohorts (validation TCGA cohort, total TCGA cohort, and GSE68465 cohort). Moreover, risk scores for genes involved in angiogenesis were independent risk factors for lung cancer in all four cohorts. The low-risk group was associated with better immune status and lower tumor mutational load. In addition, the somatic mutation study revealed that the low-risk group had a lower mutation frequency than the high-risk group. According to an analysis of tumor stem cell infiltration, HLA expression, and TIDE scores, the low-risk group had higher TIDE scores and HLA expression levels than the high-risk group, and the amount of tumor stem cell infiltration correlated with the risk score. In addition, high-risk groups may benefit from immune checkpoint inhibitors and targeted therapies. In conclusion, we developed an angiogenesis-related gene risk model to predict the prognosis of LUAD patients, which may aid in the classification of patients with LUAD and select medications for LUAD patients.
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Reviewed by: Hua Huang, Tianjin Medical University, China
These authors have contributed equally to this work
Guangsheng Zhu, Tianjin Medical University General Hospital, China
Edited by: Apostolos Zaravinos, European University Cyprus, Cyprus
This article was submitted to Cancer Genetics and Oncogenomics, a section of the journal Frontiers in Genetics
ISSN:1664-8021
1664-8021
DOI:10.3389/fgene.2023.1092968