Isoflurane Modulates Hippocampal Cornu Ammonis Pyramidal Neuron Excitability by Inhibition of Both Transient and Persistent Sodium Currents in Mice

Volatile anesthetics inhibit presynaptic voltage-gated sodium channels to reduce neurotransmitter release, but their effects on excitatory neuron excitability by sodium current inhibition are unclear. The authors hypothesized that inhibition of transient and persistent neuronal sodium currents by th...

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Vydané v:	Anesthesiology (Philadelphia) Ročník 131; číslo 1; s. 94
Hlavní autori:	Zhao, Wenling, Zhang, Mingyue, Liu, Jin, Liang, Peng, Wang, Rurong, Hemmings, Hugh C, Zhou, Cheng
Médium:	Journal Article
Jazyk:	English
Vydavateľské údaje:	United States 01.07.2019
Predmet:	Action Potentials Anesthetics, Inhalation - pharmacology Animals Female Hippocampus - drug effects Isoflurane - pharmacology Male Mice Models, Animal Pyramidal Cells - drug effects Sodium Channels - drug effects
ISSN:	1528-1175, 1528-1175
On-line prístup:	Zistit podrobnosti o prístupe
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