Isoflurane Modulates Hippocampal Cornu Ammonis Pyramidal Neuron Excitability by Inhibition of Both Transient and Persistent Sodium Currents in Mice

Volatile anesthetics inhibit presynaptic voltage-gated sodium channels to reduce neurotransmitter release, but their effects on excitatory neuron excitability by sodium current inhibition are unclear. The authors hypothesized that inhibition of transient and persistent neuronal sodium currents by th...

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Bibliographic Details

Published in:	Anesthesiology (Philadelphia) Vol. 131; no. 1; p. 94
Main Authors:	Zhao, Wenling, Zhang, Mingyue, Liu, Jin, Liang, Peng, Wang, Rurong, Hemmings, Hugh C, Zhou, Cheng
Format:	Journal Article
Language:	English
Published:	United States 01.07.2019
Subjects:	Action Potentials Anesthetics, Inhalation - pharmacology Animals Female Hippocampus - drug effects Isoflurane - pharmacology Male Mice Models, Animal Pyramidal Cells - drug effects Sodium Channels - drug effects
ISSN:	1528-1175, 1528-1175
Online Access:	Get more information
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