Precision Medicine in the Diagnosis and Management of Orthopedic Biofilm Infections

Orthopedic biofilm infections are difficult to treat and require a multidisciplinary approach to diagnostics and management. Recent advances in the field include methods to disrupt biofilm, sequencing tools, and antibiotic susceptibility tests for bacteria residing in biofilm. The observation of int...

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Bibliographic Details
Published in:Frontiers in medicine Vol. 7; p. 580671
Main Authors: Baldan, Rossella, Sendi, Parham
Format: Journal Article
Language:English
Published: Lausanne Frontiers Media SA 10.11.2020
Frontiers Media S.A
Subjects:
Antibiotics
Antimicrobial agents
Biofilms
Diagnostic tests
Genomes
Global health
Health care industry
implant-related infection
Infections
Medicine
Meta-analysis
metagenomic sequencing
Microorganisms
minimal biofilm eradication concentration
next-generation sequencing
Orthopedics
osteomyelitis
Pathogens
Patients
Precision medicine
Systematic review
Transplants & implants
United States > US
ISSN:2296-858X, 2296-858X
Online Access:Get full text
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Description
Summary:Orthopedic biofilm infections are difficult to treat and require a multidisciplinary approach to diagnostics and management. Recent advances in the field include methods to disrupt biofilm, sequencing tools, and antibiotic susceptibility tests for bacteria residing in biofilm. The observation of interclonal differences in biofilm properties of the causative microorganisms, together with considerations of comorbidities and polypharmacy in a growing aging population, calls for a personalized approach to treat these infections. In this article, we highlight aspects of precision medicine that may open new perspectives in the diagnosis and management of orthopedic biofilm infections.
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Reviewed by: Laura Morata, Hospital Clínic de Barcelona, Spain; Marjan Wouthuyzen-Bakker, University Medical Center Groningen, Netherlands
This article was submitted to Infectious Diseases - Surveillance, Prevention and Treatment, a section of the journal Frontiers in Medicine
Edited by: Alex Soriano, Hospital Clínic de Barcelona, Spain
ISSN:2296-858X
2296-858X
DOI:10.3389/fmed.2020.580671