Aptamers and MIPs as alternative molecular recognition elements for vasopressin and oxytocin sensing: A review

Arginine vasopressin (AVP) and oxytocin (OT) are two important hormones that regulate various physiological and behavioral functions, such as blood pressure, water balance, social bonding, and stress response. The detection and quantification of these hormones are of great interest in clinical diagn...

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Bibliographic Details
Published in:Biosensors & bioelectronics Vol. 278; p. 117306
Main Authors: Beke, Essohanam, Gondran, Chantal, Chovelon, Benoît, Peyrin, Eric, Holzinger, Michael, Ravelet, Corinne
Format: Journal Article
Language:English
Published: England Elsevier B.V 15.06.2025
Elsevier
Subjects:
Analytical chemistry
Animals
Aptamers, Nucleotide - chemistry
arginine vasopressin
Bioengineering
Biosensing Techniques - methods
biosensors
blood pressure
Chemical Sciences
Endocrinology and metabolism
ethics
Human health and pathology
Humans
Life Sciences
molecular imprinting
Molecularly Imprinted Polymers - chemistry
nucleic acids
oligonucleotides
oxytocin
Oxytocin - analysis
Oxytocin - chemistry
Oxytocin - isolation & purification
stress response
Vasopressins - analysis
Vasopressins - isolation & purification
arginine vasopressin
oxytocin
aptamers
molecularly imprinted polymers
ISSN:0956-5663, 1873-4235, 1873-4235
Online Access:Get full text
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Summary:Arginine vasopressin (AVP) and oxytocin (OT) are two important hormones that regulate various physiological and behavioral functions, such as blood pressure, water balance, social bonding, and stress response. The detection and quantification of these hormones are of great interest in clinical diagnosis and research. However, the conventional methods based on antibodies or enzymes have some limitations, such as high cost, low stability, and ethical issues. Therefore, alternative molecular recognition elements, such as aptamers and molecularly imprinted polymers (MIPs), have been developed to overcome these drawbacks. Aptamers are short nucleic acid sequences that can bind to specific targets with high affinity and specificity, while MIPs are synthetic polymers with imprinted binding sites mimicking natural receptors. Both aptamers and MIPs have advantages such as low cost, high stability, easy synthesis, and modification. In this review, we summarize the recent advances in the development and application of aptamers and MIPs for the sensing of vasopressin and oxytocin, and compare their performances. We also discuss the challenges and future perspectives of aptamers and MIPs as alternative molecular recognition elements for vasopressin and oxytocin sensing. •Review on aptamer- and MIP-based biosensors for the detection of arginine vasopressin and oxytocin.•Presentation of the signaling mechanisms implemented for the development of aptamer and MIP-based biosensors.•Overview of optical, electrochemical and electrical transduction methods.
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ISSN:0956-5663
1873-4235
1873-4235
DOI:10.1016/j.bios.2025.117306