Borna disease virus phosphoprotein triggers the organization of viral inclusion bodies by liquid-liquid phase separation

Inclusion bodies (IBs) are characteristic biomolecular condensates organized by the non-segmented negative-strand RNA viruses belonging to the order Mononegavirales. Although recent studies have revealed the characteristics of IBs formed by cytoplasmic mononegaviruses, that of Borna disease virus 1...

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Bibliographic Details
Published in:	International journal of biological macromolecules Vol. 192; pp. 55 - 63
Main Authors:	Hirai, Yuya, Tomonaga, Keizo, Horie, Masayuki
Format:	Journal Article
Language:	English
Published:	Netherlands Elsevier B.V 01.12.2021
Subjects:	Animals Biomolecular condensates Biomolecular Condensates - metabolism Biomolecular Condensates - pathology Borna Disease - metabolism Borna Disease - pathology Borna Disease - virology Borna disease virus Borna disease virus - physiology Cell Fractionation - methods cell nucleus Cells, Cultured chronic diseases Fluorescent Antibody Technique Inclusion Bodies, Viral - metabolism Inclusion Bodies, Viral - pathology Intrinsically disordered regions Liquid droplets Liquid-Liquid Extraction Liquid-liquid phase separation liquids Membraneless organelles Microscopy, Confocal Mononegavirus Non-segmented negative-strand RNA viruses Nucleoprotein nucleoproteins Nucleus Phosphoprotein phosphoproteins Phosphoproteins - metabolism RNA separation Viral Proteins - metabolism Nucleus Liquid droplets Borna disease virus Non-segmented negative-strand RNA viruses Intrinsically disordered regions Membraneless organelles Nucleoprotein Mononegavirus Phosphoprotein Liquid-liquid phase separation Biomolecular condensates
ISSN:	0141-8130, 1879-0003, 1879-0003
Online Access:	Get full text
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