Translating complexity and heterogeneity of pancreatic tumor: 3D in vitro to in vivo models

[Display omitted] Pancreatic ductal adenocarcinoma (PDAC) is an extremely aggressive type of cancer with an overall survival rate of less than 7–8%, emphasizing the need for novel effective therapeutics against PDAC. However only a fraction of therapeutics which seemed promising in the laboratory en...

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Veröffentlicht in:	Advanced drug delivery reviews Jg. 174; S. 265 - 293
Hauptverfasser:	Heinrich, Marcel A., Mostafa, Ahmed M.R.H., Morton, Jennifer P., Hawinkels, Lukas J.A.C., Prakash, Jai
Format:	Journal Article
Sprache:	Englisch
Veröffentlicht:	Netherlands Elsevier B.V 01.07.2021
Schlagworte:	Animals Bioprinting Carcinoma, Pancreatic Ductal - drug therapy Carcinoma, Pancreatic Ductal - pathology Disease Models, Animal Disease Progression Drug Development - methods Genetically engineered mouse models Humans Mice Mice, Transgenic Models, Biological Pancreatic ductal adenocarcinoma Pancreatic Neoplasms - drug therapy Pancreatic Neoplasms - pathology Tumor Microenvironment Tumor-on-chip Bioprinting Genetically engineered mouse models Tumor-on-chip Tumor microenvironment Pancreatic ductal adenocarcinoma
ISSN:	0169-409X, 1872-8294, 1872-8294
Online-Zugang:	Volltext
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