Nlrp3 is a key modulator of diet-induced nephropathy and renal cholesterol accumulation

Metabolic syndrome (MetSyn) is a major health concern and associates with the development of kidney disease. The mechanisms linking MetSyn to renal disease have not been fully elucidated but are known to involve hyperuricemia, inflammation, and fibrosis. Since the innate immune receptor Nlrp3 is an...

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Vydané v:	Kidney international Ročník 85; číslo 5; s. 1112 - 1122
Hlavní autori:	Bakker, Pieter J., Butter, Loes M., Kors, Lotte, Teske, Gwendoline J.D., Aten, Jan, Sutterwala, Fayyaz S., Florquin, Sandrine, Leemans, Jaklien C.
Médium:	Journal Article
Jazyk:	English
Vydavateľské údaje:	United States Elsevier Inc 01.05.2014 Elsevier Limited
Predmet:	Animals Biomarkers - blood Carrier Proteins - genetics Carrier Proteins - metabolism Cholesterol, Dietary - metabolism chronic nephropathy Diet, High-Fat Diet, Western Dietary Carbohydrates - metabolism Disease Models, Animal dyslipidemia Fibrosis Fructose - metabolism immunology and pathology Inflammasomes - immunology Inflammasomes - metabolism Kidney - immunology Kidney - metabolism Kidney - pathology Kidney Diseases - etiology Kidney Diseases - genetics Kidney Diseases - immunology Kidney Diseases - metabolism Kidney Diseases - pathology Macrophages - immunology Macrophages - metabolism Male Metabolic Syndrome - etiology Metabolic Syndrome - genetics Metabolic Syndrome - immunology Metabolic Syndrome - metabolism Metabolic Syndrome - pathology Mice, Inbred C57BL Mice, Knockout NLR Family, Pyrin Domain-Containing 3 Protein obesity Receptors, LDL - metabolism Signal Transduction Sterol Regulatory Element Binding Protein 2 - metabolism immunology and pathology chronic nephropathy dyslipidemia obesity
ISSN:	0085-2538, 1523-1755, 1523-1755
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