Predictors and clinical relevance of ventricular tachyarrhythmias in ambulatory patients with a continuous flow left ventricular assist device

Patients with a left ventricular assist device (LVAD) are at high risk for ventricular tachyarrhythmias (VTAs). We aimed to identify clinical predictors of VTAs and subsequent outcomes after VTA in ambulatory LVAD patients. A retrospective study of 149 patients with a continuous flow HeartMate II LV...

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Veröffentlicht in:Heart rhythm Jg. 13; H. 5; S. 1052 - 1056
Hauptverfasser: Yoruk, Ayhan, Sherazi, Saadia, Massey, H Todd, Kutyifa, Valentina, McNitt, Scott, Hallinan, William, Huang, David T, Chen, Leway, Aktas, Mehmet K
Format: Journal Article
Sprache:Englisch
Veröffentlicht: United States 01.05.2016
Schlagworte:
Adult
Aged
Cardiac Resynchronization Therapy - adverse effects
Cardiac Resynchronization Therapy - methods
Female
Follow-Up Studies
Heart Failure - mortality
Heart Failure - physiopathology
Heart Failure - therapy
Heart-Assist Devices - adverse effects
Humans
Male
Middle Aged
Proportional Hazards Models
Risk Factors
Tachycardia, Ventricular - diagnosis
Tachycardia, Ventricular - etiology
Tachycardia, Ventricular - mortality
Tachycardia, Ventricular - prevention & control
Treatment Outcome
United States - epidemiology
Ventricular Function, Left
Left ventricular assist device
Ventricular tachycardia
Implantable cardioverter-defibrillator
Atrial fibrillation
Ventricular fibrillation
ISSN:1556-3871
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Zusammenfassung:Patients with a left ventricular assist device (LVAD) are at high risk for ventricular tachyarrhythmias (VTAs). We aimed to identify clinical predictors of VTAs and subsequent outcomes after VTA in ambulatory LVAD patients. A retrospective study of 149 patients with a continuous flow HeartMate II LVAD who survived to discharge from index hospitalization after LVAD implantation was performed from January 10, 2005, to September 3, 2013. A multivariate Cox model was used to assess clinical predictors of VTAs. During a mean follow-up period of 2.1 ± 1.2 years, 41 patients (28%) experienced VTAs; 30 of these patients (71%) had ventricular tachycardia, and 11 (29%) had ventricular fibrillation. History of VTAs before LVAD (hazard ratio [HR] 3.06; 95% confidence interval [CI] 1.57-5.96; P = .001) and history of atrial fibrillation (AF) (HR 3.13; 95% CI 1.60-6.11; P = .008) were the most powerful predictors of VTAs after LVAD implantation. There were 19 deaths (46%) among patients with VTAs and 15 deaths (14%) among patients without VTAs (P < .001). In multivariate analysis, time-dependent VTAs after LVAD implantation were associated with a significantly higher risk of all-cause mortality when compared with those without VTAs (HR 7.28; 95% CI 3.50-15.15; P < .001). In ambulatory LVAD patients, history of VTAs before LVAD implantation and history of AF predict VTAs after LVAD implantation. VTAs are associated with an increased risk of mortality. In such patients, aggressive measures to control VTAs and AF should be considered.
Bibliographie:ObjectType-Article-1
SourceType-Scholarly Journals-1
ObjectType-Feature-2
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ISSN:1556-3871
DOI:10.1016/j.hrthm.2016.01.033