Impact of list-mode reconstruction and image-space point spread function correction on PET image contrast and quantitative value using SiPM-based PET/CT system

We evaluate the effects of list-mode reconstruction and the image-space point spread function (iPSF) on the contrast and quantitative values of positron emission tomography (PET) images using a SiPM-PET/CT system. The evaluation is conducted on an NEMA body phantom and clinical images using a Cartes...

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Bibliographic Details
Published in:Radiological Physics and Technology Vol. 16; no. 3; pp. 384 - 396
Main Authors: Shirakawa, Yuya, Matsutomo, Norikazu
Format: Journal Article
Language:English
Published: Singapore Springer Science and Business Media LLC 01.09.2023
Springer Nature Singapore
Subjects:
Algorithms
Fluorodeoxyglucose F18
Image Processing, Computer-Assisted
Imaging
Medical and Radiation Physics
Medicine
Medicine & Public Health
Nuclear Medicine
Phantoms, Imaging
Positron Emission Tomography Computed Tomography
Positron-Emission Tomography
Radiology
Radiotherapy
Research Article
Image space PSF correction
SiPM-PET/CT
List-mode reconstruction
SUV
ISSN:1865-0333, 1865-0341, 1865-0341
Online Access:Get full text
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Summary:We evaluate the effects of list-mode reconstruction and the image-space point spread function (iPSF) on the contrast and quantitative values of positron emission tomography (PET) images using a SiPM-PET/CT system. The evaluation is conducted on an NEMA body phantom and clinical images using a Cartesion Prime SiPM-PET/CT system. The signal-to-background ratio (SBR) of the phantom is set to 2, 4, 6, and 8, and all the PET image data are obtained and reconstructed using 3D-OSEM, time-of-flight, iPSF (−/ +), and a 4-mm Gaussian filter with several iterations. The evaluation criteria include % background variability ( N B,10 mm ), % contrast ( Q H,10 mm ), iPSF change in Q H,10 mm (Δ Q H,10 mm ) for edge artifact evaluation, profile curves, visual evaluation of edge artifacts, clinical imaging for the standardized uptake value (SUV) of lung nodules, and SNR liver . N B,10 mm demonstrates no significant difference in all SBRs with and without iPSF, whereas Q H,10 mm is higher based on the SBR with and without iPSF. Δ Q H,10 mm indicates increased iterations and a larger rate of change (> 5%) for small spheres of < 17 mm. The profile curves portrayed almost real concentrations, except for the 10-mm sphere of SBR2 without iPSF; however, with iPSF, an overshoot was observed in the 13-mm sphere of all SBRs. The degree of overshoot increased with increasing iteration and SBR. Edge artifacts were detected at values ≥ 17–22 mm in SBRs other than SBR2 with iPSF. Irrespective of the nodal size, SUV and SNR liver improved considerably after iPSF adjustment. Therefore, the effects of list-mode reconstruction and iPSF on PET image contrast were limited, and the overcorrection of the quantitative values was validated using iPSF.
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ISSN:1865-0333
1865-0341
1865-0341
DOI:10.1007/s12194-023-00729-y