Sugar-based amphiphilic nanoparticles arrest atherosclerosis in vivo

Atherosclerosis, the build-up of occlusive, lipid-rich plaques in arterial walls, is a focal trigger of chronic coronary, intracranial, and peripheral arterial diseases, which together account for the leading causes of death worldwide. Although the directed treatment of atherosclerotic plaques remai...

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Bibliographic Details
Published in:	Proceedings of the National Academy of Sciences - PNAS Vol. 112; no. 9; p. 2693
Main Authors:	Lewis, Daniel R, Petersen, Latrisha K, York, Adam W, Zablocki, Kyle R, Joseph, Laurie B, Kholodovych, Vladyslav, Prud'homme, Robert K, Uhrich, Kathryn E, Moghe, Prabhas V
Format:	Journal Article
Language:	English
Published:	United States 03.03.2015
Subjects:	Animals Atherosclerosis - drug therapy Atherosclerosis - genetics Atherosclerosis - metabolism Atherosclerosis - pathology Carbohydrates CD36 Antigens - genetics CD36 Antigens - metabolism Humans Hyperplasia - genetics Hyperplasia - metabolism Hyperplasia - pathology Lipids Macrophages - metabolism Macrophages - pathology Mice Mice, Knockout Nanoparticles Neointima - genetics Neointima - metabolism Neointima - pathology Oxidation-Reduction Plaque, Atherosclerotic - blood Plaque, Atherosclerotic - drug therapy Plaque, Atherosclerotic - genetics Plaque, Atherosclerotic - metabolism Plaque, Atherosclerotic - pathology Scavenger Receptors, Class A - genetics Scavenger Receptors, Class A - metabolism atherosclerosis nanomedicine macrophages biomaterials
ISSN:	1091-6490, 1091-6490
Online Access:	Get more information
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