Tissue-Resident-Memory CD8+ T Cells Bridge Innate Immune Responses in Neighboring Epithelial Cells to Control Human Genital Herpes

Tissue-resident-memory T cells (TRM) populate the body’s barrier surfaces, functioning as frontline responders against reencountered pathogens. Understanding of the mechanisms by which CD8TRM achieve effective immune protection remains incomplete in a naturally recurring human disease. Using laser c...

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Bibliographic Details
Published in:	Frontiers in immunology Vol. 12; p. 735643
Main Authors:	Peng, Tao, Phasouk, Khamsone, Sodroski, Catherine N., Sun, Sijie, Hwangbo, Yon, Layton, Erik D., Jin, Lei, Klock, Alexis, Diem, Kurt, Magaret, Amalia S., Jing, Lichen, Laing, Kerry, Li, Alvason, Huang, Meei-Li, Mertens, Max, Johnston, Christine, Jerome, Keith R., Koelle, David M., Wald, Anna, Knipe, David M., Corey, Lawrence, Zhu, Jia
Format:	Journal Article
Language:	English
Published:	Switzerland Frontiers Media S.A 06.09.2021
Subjects:	Adaptive Immunity - genetics Adult Aged Antigens, Viral - immunology CD8-Positive T-Lymphocytes - immunology CD8-Positive T-Lymphocytes - metabolism CD8-Positive T-Lymphocytes - virology cell-intrinsic immunity Cells, Cultured Epithelial Cells - immunology Epithelial Cells - metabolism Epithelial Cells - virology Female Gene Expression Profiling Herpes Genitalis - genetics Herpes Genitalis - immunology Herpes Genitalis - metabolism Herpes Genitalis - virology Herpesvirus 2, Human - immunology Herpesvirus 2, Human - pathogenicity Host-Pathogen Interactions human genital herpes Humans IFI16 restriction factor Immunity, Innate - genetics Immunologic Memory Immunology innate antiviral response Interferon-gamma - genetics Interferon-gamma - metabolism Male Memory T Cells - immunology Memory T Cells - metabolism Memory T Cells - virology Middle Aged Phenotype Skin - immunology Skin - metabolism Skin - virology tissue microenvironment tissue-resident-memory T cells (TRM) Transcriptome innate antiviral response cell-intrinsic immunity human genital herpes tissue-resident-memory T cells (TRM) IFI16 restriction factor tissue microenvironment
ISSN:	1664-3224, 1664-3224
Online Access:	Get full text
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