Inactivated tick-borne encephalitis vaccine elicits several overlapping waves of T cell response

The development and implementation of vaccines have been growing exponentially, remaining one of the major successes of healthcare over the last century. Nowadays, active regular immunizations prevent epidemics of many viral diseases, including tick-borne encephalitis (TBE). Along with the generatio...

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Vydáno v:	Frontiers in immunology Ročník 13; s. 970285
Hlavní autoři:	Sycheva, Anastasiia L., Komech, Ekaterina A., Pogorelyy, Mikhail V., Minervina, Anastasia A., Urazbakhtin, Shamil Z., Salnikova, Maria A., Vorovitch, Mikhail F., Kopantzev, Eugene P., Zvyagin, Ivan V., Komkov, Alexander Y., Mamedov, Ilgar Z., Lebedev, Yuri B.
Médium:	Journal Article
Jazyk:	angličtina
Vydáno:	Switzerland Frontiers Media S.A 24.08.2022
Témata:	Antibodies, Viral CD8-Positive T-Lymphocytes clonal expansion Encephalitis Viruses, Tick-Borne Encephalitis, Tick-Borne - prevention & control Humans immunological memory Immunology T cell immune response TBE vaccination TCR motif TCR repertoire Viral Vaccines TBE vaccination tick-borne encephalitis TCR motif T cell immune response immunological memory clonal expansion TCR repertoire
ISSN:	1664-3224, 1664-3224
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Abstract	The development and implementation of vaccines have been growing exponentially, remaining one of the major successes of healthcare over the last century. Nowadays, active regular immunizations prevent epidemics of many viral diseases, including tick-borne encephalitis (TBE). Along with the generation of virus-specific antibodies, a highly effective vaccine should induce T cell responses providing long-term immune defense. In this study, we performed longitudinal high-throughput T cell receptor (TCR) sequencing to characterize changes in individual T cell repertoires of 11 donors immunized with an inactivated TBE vaccine. After two-step immunization, we found significant clonal expansion of both CD4 + and CD8 + T cells, ranging from 302 to 1706 vaccine-associated TCRβ clonotypes in different donors. We detected several waves of T cell clonal expansion generated by distinct groups of vaccine-responding clones. Both CD4 + and CD8 + vaccine-responding T cell clones formed 17 motifs in TCRβ sequences shared by donors with identical HLA alleles. Our results indicate that TBE vaccination leads to a robust T cell response due to the production of a variety of T cell clones with a memory phenotype, which recognize a large set of epitopes.
AbstractList	The development and implementation of vaccines have been growing exponentially, remaining one of the major successes of healthcare over the last century. Nowadays, active regular immunizations prevent epidemics of many viral diseases, including tick-borne encephalitis (TBE). Along with the generation of virus-specific antibodies, a highly effective vaccine should induce T cell responses providing long-term immune defense. In this study, we performed longitudinal high-throughput T cell receptor (TCR) sequencing to characterize changes in individual T cell repertoires of 11 donors immunized with an inactivated TBE vaccine. After two-step immunization, we found significant clonal expansion of both CD4 + and CD8 + T cells, ranging from 302 to 1706 vaccine-associated TCRβ clonotypes in different donors. We detected several waves of T cell clonal expansion generated by distinct groups of vaccine-responding clones. Both CD4 + and CD8 + vaccine-responding T cell clones formed 17 motifs in TCRβ sequences shared by donors with identical HLA alleles. Our results indicate that TBE vaccination leads to a robust T cell response due to the production of a variety of T cell clones with a memory phenotype, which recognize a large set of epitopes. The development and implementation of vaccines have been growing exponentially, remaining one of the major successes of healthcare over the last century. Nowadays, active regular immunizations prevent epidemics of many viral diseases, including tick-borne encephalitis (TBE). Along with the generation of virus-specific antibodies, a highly effective vaccine should induce T cell responses providing long-term immune defense. In this study, we performed longitudinal high-throughput T cell receptor (TCR) sequencing to characterize changes in individual T cell repertoires of 11 donors immunized with an inactivated TBE vaccine. After two-step immunization, we found significant clonal expansion of both CD4+ and CD8+ T cells, ranging from 302 to 1706 vaccine-associated TCRβ clonotypes in different donors. We detected several waves of T cell clonal expansion generated by distinct groups of vaccine-responding clones. Both CD4+ and CD8+ vaccine-responding T cell clones formed 17 motifs in TCRβ sequences shared by donors with identical HLA alleles. Our results indicate that TBE vaccination leads to a robust T cell response due to the production of a variety of T cell clones with a memory phenotype, which recognize a large set of epitopes. The development and implementation of vaccines have been growing exponentially, remaining one of the major successes of healthcare over the last century. Nowadays, active regular immunizations prevent epidemics of many viral diseases, including tick-borne encephalitis (TBE). Along with the generation of virus-specific antibodies, a highly effective vaccine should induce T cell responses providing long-term immune defense. In this study, we performed longitudinal high-throughput T cell receptor (TCR) sequencing to characterize changes in individual T cell repertoires of 11 donors immunized with an inactivated TBE vaccine. After two-step immunization, we found significant clonal expansion of both CD4 and CD8 T cells, ranging from 302 to 1706 vaccine-associated TCRβ clonotypes in different donors. We detected several waves of T cell clonal expansion generated by distinct groups of vaccine-responding clones. Both CD4 and CD8 vaccine-responding T cell clones formed 17 motifs in TCRβ sequences shared by donors with identical HLA alleles. Our results indicate that TBE vaccination leads to a robust T cell response due to the production of a variety of T cell clones with a memory phenotype, which recognize a large set of epitopes. The development and implementation of vaccines have been growing exponentially, remaining one of the major successes of healthcare over the last century. Nowadays, active regular immunizations prevent epidemics of many viral diseases, including tick-borne encephalitis (TBE). Along with the generation of virus-specific antibodies, a highly effective vaccine should induce T cell responses providing long-term immune defense. In this study, we performed longitudinal high-throughput T cell receptor (TCR) sequencing to characterize changes in individual T cell repertoires of 11 donors immunized with an inactivated TBE vaccine. After two-step immunization, we found significant clonal expansion of both CD4+ and CD8+ T cells, ranging from 302 to 1706 vaccine-associated TCRβ clonotypes in different donors. We detected several waves of T cell clonal expansion generated by distinct groups of vaccine-responding clones. Both CD4+ and CD8+ vaccine-responding T cell clones formed 17 motifs in TCRβ sequences shared by donors with identical HLA alleles. Our results indicate that TBE vaccination leads to a robust T cell response due to the production of a variety of T cell clones with a memory phenotype, which recognize a large set of epitopes.The development and implementation of vaccines have been growing exponentially, remaining one of the major successes of healthcare over the last century. Nowadays, active regular immunizations prevent epidemics of many viral diseases, including tick-borne encephalitis (TBE). Along with the generation of virus-specific antibodies, a highly effective vaccine should induce T cell responses providing long-term immune defense. In this study, we performed longitudinal high-throughput T cell receptor (TCR) sequencing to characterize changes in individual T cell repertoires of 11 donors immunized with an inactivated TBE vaccine. After two-step immunization, we found significant clonal expansion of both CD4+ and CD8+ T cells, ranging from 302 to 1706 vaccine-associated TCRβ clonotypes in different donors. We detected several waves of T cell clonal expansion generated by distinct groups of vaccine-responding clones. Both CD4+ and CD8+ vaccine-responding T cell clones formed 17 motifs in TCRβ sequences shared by donors with identical HLA alleles. Our results indicate that TBE vaccination leads to a robust T cell response due to the production of a variety of T cell clones with a memory phenotype, which recognize a large set of epitopes.
Author	Salnikova, Maria A. Komech, Ekaterina A. Vorovitch, Mikhail F. Komkov, Alexander Y. Mamedov, Ilgar Z. Sycheva, Anastasiia L. Pogorelyy, Mikhail V. Kopantzev, Eugene P. Urazbakhtin, Shamil Z. Zvyagin, Ivan V. Lebedev, Yuri B. Minervina, Anastasia A.
AuthorAffiliation	2 Department of Molecular Technologies, Institute of Translational Medicine, Pirogov Russian National Research Medical University , Moscow , Russia 1 Department of Genomics of Adaptive Immunity, Shemyakin-Ovchinnikov Institute of Bioorganic Chemistry RAS , Moscow , Russia 4 Computational Systems Biochemistry Research Group, Max Planck Institute of Biochemistry , Martinsried , Germany 3 Department of Immunology, St. Jude Children’s Research Hospital , Memphis, TN , United States 9 Laboratory of Cytogenetics and Molecular Genetics, Dmitry Rogachev National Medical and Research Centre of Paediatric Haematology, Oncology and Immunology , Moscow , Russia 7 Department of Organization and Technology of Production of Immune-and-Biological Products, Institute for Translational Medicine and Biotechnology, Sechenov First Moscow State Medical University , Moscow , Russia 6 Laboratory of Tick-Borne Encephalitis and Other Encephalitis, Chumakov Federal Scientific Center for Research and Development of Imm
AuthorAffiliation_xml	– name: 2 Department of Molecular Technologies, Institute of Translational Medicine, Pirogov Russian National Research Medical University , Moscow , Russia – name: 6 Laboratory of Tick-Borne Encephalitis and Other Encephalitis, Chumakov Federal Scientific Center for Research and Development of Immune-and-Biological Products of RAS (FSASI “Chumakov FSC R&D IBP RAS”) , Moscow , Russia – name: 5 Department of Immunology, Faculty of Biology, Lomonosov Moscow State University , Moscow , Russia – name: 1 Department of Genomics of Adaptive Immunity, Shemyakin-Ovchinnikov Institute of Bioorganic Chemistry RAS , Moscow , Russia – name: 7 Department of Organization and Technology of Production of Immune-and-Biological Products, Institute for Translational Medicine and Biotechnology, Sechenov First Moscow State Medical University , Moscow , Russia – name: 4 Computational Systems Biochemistry Research Group, Max Planck Institute of Biochemistry , Martinsried , Germany – name: 8 Department of Genomics and Postgenomic Technologies, Shemyakin-Ovchinnikov Institute of Bioorganic Chemistry RAS , Moscow , Russia – name: 3 Department of Immunology, St. Jude Children’s Research Hospital , Memphis, TN , United States – name: 9 Laboratory of Cytogenetics and Molecular Genetics, Dmitry Rogachev National Medical and Research Centre of Paediatric Haematology, Oncology and Immunology , Moscow , Russia
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BackLink	https://www.ncbi.nlm.nih.gov/pubmed/36091004$$D View this record in MEDLINE/PubMed
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Copyright	Copyright © 2022 Sycheva, Komech, Pogorelyy, Minervina, Urazbakhtin, Salnikova, Vorovitch, Kopantzev, Zvyagin, Komkov, Mamedov and Lebedev. Copyright © 2022 Sycheva, Komech, Pogorelyy, Minervina, Urazbakhtin, Salnikova, Vorovitch, Kopantzev, Zvyagin, Komkov, Mamedov and Lebedev 2022 Sycheva, Komech, Pogorelyy, Minervina, Urazbakhtin, Salnikova, Vorovitch, Kopantzev, Zvyagin, Komkov, Mamedov and Lebedev
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Keywords	TBE vaccination tick-borne encephalitis TCR motif T cell immune response immunological memory clonal expansion TCR repertoire
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Snippet	The development and implementation of vaccines have been growing exponentially, remaining one of the major successes of healthcare over the last century....
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SubjectTerms	Antibodies, Viral CD8-Positive T-Lymphocytes clonal expansion Encephalitis Viruses, Tick-Borne Encephalitis, Tick-Borne - prevention & control Humans immunological memory Immunology T cell immune response TBE vaccination TCR motif TCR repertoire Viral Vaccines
Title	Inactivated tick-borne encephalitis vaccine elicits several overlapping waves of T cell response
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