Usefulness of iodine-blood material density images in estimating degree of liver fibrosis by calculating extracellular volume fraction obtained from routine dual-energy liver CT protocol equilibrium phase data: preliminary experience

Purpose To assess whether extracellular volume fraction (ECV) calculated from iodine(-blood) density images (I-B) of dual-energy liver CT (DECT) equilibrium phase data (EqD) is useful in estimating the degree of liver fibrosis. Materials and methods Consecutive 52 patients with chronic liver disease...

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Vydané v:	Japanese journal of radiology Ročník 38; číslo 4; s. 365 - 373
Hlavní autori:	Ito, Emi, Sato, Keisuke, Yamamoto, Ryotaro, Sakamoto, Keiko, Urakawa, Hiroshi, Yoshimitsu, Kengo
Médium:	Journal Article
Jazyk:	English
Vydavateľské údaje:	Singapore Springer Singapore 01.04.2020 Springer Nature B.V
Predmet:	Adult Aged Aged, 80 and over Algorithms Aorta Aorta, Abdominal - diagnostic imaging Blood Contrast Media - administration & dosage Contrast Media - metabolism Correlation coefficients Density Diagnostic Tests, Routine - methods Elasticity Imaging Techniques - methods Estimation Female Fibrosis Humans Imaging Iodine Iodine - administration & dosage Iodine - blood Liver Liver Cirrhosis - diagnostic imaging Liver diseases Male Mathematical analysis Medical imaging Medicine Medicine & Public Health Middle Aged Nuclear Medicine Original Article Radiology Radiotherapy Retrospective Studies Stiffness Tomography, X-Ray Computed - methods Vena Cava, Inferior - diagnostic imaging Iodine(-blood) density images Equilibrium phase Extracellular volume fraction Dual-energy CT Liver fibrosis
ISSN:	1867-1071, 1867-108X, 1867-108X
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Shrnutí:	Purpose To assess whether extracellular volume fraction (ECV) calculated from iodine(-blood) density images (I-B) of dual-energy liver CT (DECT) equilibrium phase data (EqD) is useful in estimating the degree of liver fibrosis. Materials and methods Consecutive 52 patients with chronic liver disease who underwent fast kV switching DECT and liver MR elastography (MRE) were retrospectively enrolled. Iodine(-water) density images (I-W) and I-B generated from EqD and ECV were calculated. As blood pools, abdominal aorta (Ao) and suprahepatic inferior vena cava (IVC) were chosen, and, therefore, 4 types of ECV (ECV I-W Ao , ECV I-W IVC , ECV I-B Ao , ECV I-B IVC ) were obtained. ECV was also calculated using conventional method (ECV conv Ao ). The correlation coefficients ( R 2 or rho) of these five ECVs versus liver stiffness (MRE) or pathologically proven fibrosis grades were compared. Results As for correlation with liver stiffness, R 2 for ECV conv.Ao , ECV I-W Ao , ECV I-B Ao , ECV I-W IVC , and ECV I-B IVC , were 0.26, 0.34, 0.44, 0.39, and 0.52, respectively (all p < 0.0001). Histopathological correlation was available in 28 patients, and rho values were 0.61, 0.60, 0.71, 0.68, and 0.76, respectively (all p < 0.001). Conclusion ECV I–B IVC calculated from EqD of DECT is useful in estimating the degree of liver fibrosis.
Bibliografia:	ObjectType-Article-1 SourceType-Scholarly Journals-1 ObjectType-Feature-2 content type line 14 content type line 23
ISSN:	1867-1071 1867-108X 1867-108X
DOI:	10.1007/s11604-019-00918-z