HDAC3 Mediates the Inflammatory Response and LPS Tolerance in Human Monocytes and Macrophages

Histone deacetylases (HDACs) are a group of enzymes that control histone deacetylation and bear potential to direct expression of large gene sets. We determined the effect of HDAC inhibitors (HDACi) on human monocytes and macrophages, with respect to their polarization, activation, and their capabil...

Ausführliche Beschreibung

Gespeichert in:

Bibliographische Detailangaben
Veröffentlicht in:	Frontiers in immunology Jg. 11; S. 550769
Hauptverfasser:	Ghiboub, Mohammed, Zhao, Jing, Li Yim, Andrew Y. F., Schilderink, Ronald, Verseijden, Caroline, van Hamersveld, Patricia H. P., Duarte, Jose M., Hakvoort, Theodorus B. M., Admiraal, Iris, Harker, Nicola R., Tough, David F., Henneman, Peter, de Winther, Menno P. J., de Jonge, Wouter J.
Format:	Journal Article
Sprache:	Englisch
Veröffentlicht:	Switzerland Frontiers Media S.A 05.10.2020
Schlagworte:	Cytokines - genetics Cytokines - metabolism Enzyme Activation Gene Expression HDAC3 inhibition Histone Deacetylase Inhibitors - pharmacology Histone Deacetylases - genetics Histone Deacetylases - metabolism Humans IFNγ Immune Tolerance - drug effects Immunology Immunophenotyping Inflammation - drug therapy Inflammation - etiology Inflammation - metabolism Inflammation - pathology inflammatory response Lipopolysaccharides - immunology LPS tolerance Macrophage Activation - drug effects Macrophage Activation - immunology macrophages Macrophages - drug effects Macrophages - immunology Macrophages - metabolism Monocytes - drug effects Monocytes - immunology Monocytes - metabolism Protein Binding IFNγ HDAC3 inhibition inflammatory response macrophages LPS tolerance
ISSN:	1664-3224, 1664-3224
Online-Zugang:	Volltext
Tags:	Tag hinzufügen Keine Tags, Fügen Sie den ersten Tag hinzu!

Schreiben Sie den ersten Kommentar!