The Role of Racial and Ethnic Factors in MicroRNA Expression and Risk for Type 2 Diabetes
Prior studies focused on circulating microRNAs and the risk for complex diseases have shown inconsistent findings. The majority of studies focused on European and East Asian racial or ethnic groups, however, ancestry was not typically reported. We evaluated the risk for type 2 diabetes as an exempla...
Uloženo v:
| Vydáno v: | Frontiers in genetics Ročník 13; s. 853633 |
|---|---|
| Hlavní autoři: | , , , |
| Médium: | Journal Article |
| Jazyk: | angličtina |
| Vydáno: |
Switzerland
Frontiers Media S.A
18.03.2022
|
| Témata: | |
| ISSN: | 1664-8021, 1664-8021 |
| On-line přístup: | Získat plný text |
| Tagy: |
Přidat tag
Žádné tagy, Buďte první, kdo vytvoří štítek k tomuto záznamu!
|
| Abstract | Prior studies focused on circulating microRNAs and the risk for complex diseases have shown inconsistent findings. The majority of studies focused on European and East Asian racial or ethnic groups, however, ancestry was not typically reported. We evaluated the risk for type 2 diabetes as an exemplar to show that race and ethnic group may contribute to inconsistent validation of previous findings of associations with microRNAs. |
|---|---|
| AbstractList | Prior studies focused on circulating microRNAs and the risk for complex diseases have shown inconsistent findings. The majority of studies focused on European and East Asian racial or ethnic groups, however, ancestry was not typically reported. We evaluated the risk for type 2 diabetes as an exemplar to show that race and ethnic group may contribute to inconsistent validation of previous findings of associations with microRNAs. Prior studies focused on circulating microRNAs and the risk for complex diseases have shown inconsistent findings. The majority of studies focused on European and East Asian racial or ethnic groups, however, ancestry was not typically reported. We evaluated the risk for type 2 diabetes as an exemplar to show that race and ethnic group may contribute to inconsistent validation of previous findings of associations with microRNAs.Prior studies focused on circulating microRNAs and the risk for complex diseases have shown inconsistent findings. The majority of studies focused on European and East Asian racial or ethnic groups, however, ancestry was not typically reported. We evaluated the risk for type 2 diabetes as an exemplar to show that race and ethnic group may contribute to inconsistent validation of previous findings of associations with microRNAs. |
| Author | Kanaya, Alka M. Flowers, Elena Zhang, Li Aouizerat, Bradley E. |
| AuthorAffiliation | 5 New York University Bluestone Center for Clinical Research , New York , NY , United States 1 University of California, San Francisco , Department of Physiological Nursing , San Francisco , CA , United States 4 University of California, San Francisco , Department of Medicine , Division of General Internal Medicine , San Francisco , CA , United States 6 New York University Department of Oral and Maxillofacial Surgery , New York , NY , United States 2 University of California, San Francisco , Institute for Human Genetics , San Francisco , CA , United States 3 University of California, San Francisco , Department of Epidemiology and Biostatistics , San Francisco , CA , United States |
| AuthorAffiliation_xml | – name: 1 University of California, San Francisco , Department of Physiological Nursing , San Francisco , CA , United States – name: 6 New York University Department of Oral and Maxillofacial Surgery , New York , NY , United States – name: 2 University of California, San Francisco , Institute for Human Genetics , San Francisco , CA , United States – name: 4 University of California, San Francisco , Department of Medicine , Division of General Internal Medicine , San Francisco , CA , United States – name: 3 University of California, San Francisco , Department of Epidemiology and Biostatistics , San Francisco , CA , United States – name: 5 New York University Bluestone Center for Clinical Research , New York , NY , United States |
| Author_xml | – sequence: 1 givenname: Elena surname: Flowers fullname: Flowers, Elena – sequence: 2 givenname: Alka M. surname: Kanaya fullname: Kanaya, Alka M. – sequence: 3 givenname: Li surname: Zhang fullname: Zhang, Li – sequence: 4 givenname: Bradley E. surname: Aouizerat fullname: Aouizerat, Bradley E. |
| BackLink | https://www.ncbi.nlm.nih.gov/pubmed/35368704$$D View this record in MEDLINE/PubMed |
| BookMark | eNp1kkFvVCEUhYmpsbX2B7gxLN3MCA8ePDYmTZ1qk6rJZFy4InfgvhnqGxjhjbH_XjrTmtZENhA49ztwOS_JUUwRCXnN2VSIzrzrVxhx2rCmmXatUEI8IydcKTnpWMOPHq2PyVkpN6wOaYQQ8gU5FrWg00yekO-LNdJ5GpCmns7BBRgoRE9n4zoGRy_BjSkXGiL9HFxO8y_ndPZ7m7GUkOJeOQ_lB-1TpovbLdKGfgiwxBHLK_K8h6Hg2f18Sr5dzhYXnybXXz9eXZxfT5xU7TjxjGHjAZhWrfEtE4z3LbbAlj2gNkaDZlpC75RU0mNXL-5aLVknhfJaozglVweuT3BjtzlsIN_aBMHuN1JeWchjcANaZyTnXhjnpZFqqZdStsJwrxrVdh5EZb0_sLa75Qa9wzhmGJ5An57EsLar9Mt2RnPFTQW8vQfk9HOHZbSbUBwOA0RMu2Kb-opqLWRTpW8ee_01efibKtAHQe17KRl768IIY-17tQ6D5czeBcHug2DvgmAPQaiV_J_KB_j_a_4AleC0vw |
| CitedBy_id | crossref_primary_10_3390_ijms25115684 crossref_primary_10_3389_fendo_2022_971354 crossref_primary_10_2147_DMSO_S428572 crossref_primary_10_3389_fonc_2023_1255527 crossref_primary_10_3389_fimmu_2024_1376416 crossref_primary_10_1159_000534041 crossref_primary_10_1210_clinem_dgac714 crossref_primary_10_1186_s10194_024_01908_x crossref_primary_10_3390_ijms25179536 |
| Cites_doi | 10.1001/jama.2021.13304 10.1007/s11892-020-01369-x 10.1038/s41598-021-83047-w 10.1056/nejmms2029562 10.2337/db20-1054 10.1016/j.molmet.2018.11.003 10.1016/s2213-8587(18)30316-4 10.2337/diacare.22.4.623 10.2337/diacare.25.12.2165 10.1136/bmjdrc-2020-001506 10.2337/diacare.23.11.1619 10.1261/rna.2183803 10.1007/s13410-020-00917-1 10.1007/s00125-015-3832-0 10.2337/db16-0592 10.3389/fphar.2021.614068 10.1038/s41598-018-32274-9 10.1186/gb-2002-3-7-research0034 10.1210/jc.2017-01909 10.1161/circresaha.110.226357 10.1016/s2213-8587(18)30051-2 |
| ContentType | Journal Article |
| Copyright | Copyright © 2022 Flowers, Kanaya, Zhang and Aouizerat. Copyright © 2022 Flowers, Kanaya, Zhang and Aouizerat. 2022 Flowers, Kanaya, Zhang and Aouizerat |
| Copyright_xml | – notice: Copyright © 2022 Flowers, Kanaya, Zhang and Aouizerat. – notice: Copyright © 2022 Flowers, Kanaya, Zhang and Aouizerat. 2022 Flowers, Kanaya, Zhang and Aouizerat |
| DBID | AAYXX CITATION NPM 7X8 5PM DOA |
| DOI | 10.3389/fgene.2022.853633 |
| DatabaseName | CrossRef PubMed MEDLINE - Academic PubMed Central (Full Participant titles) DOAJ Directory of Open Access Journals |
| DatabaseTitle | CrossRef PubMed MEDLINE - Academic |
| DatabaseTitleList | CrossRef PubMed MEDLINE - Academic |
| Database_xml | – sequence: 1 dbid: DOA name: DOAJ Directory of Open Access Journals url: https://www.doaj.org/ sourceTypes: Open Website – sequence: 2 dbid: NPM name: PubMed url: http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?db=PubMed sourceTypes: Index Database – sequence: 3 dbid: 7X8 name: MEDLINE - Academic url: https://search.proquest.com/medline sourceTypes: Aggregation Database |
| DeliveryMethod | fulltext_linktorsrc |
| Discipline | Biology |
| DocumentTitleAlternate | Flowers et al |
| EISSN | 1664-8021 |
| ExternalDocumentID | oai_doaj_org_article_c9411d39cd4946b7b445391d62658da3 PMC8971619 35368704 10_3389_fgene_2022_853633 |
| Genre | Journal Article |
| GrantInformation_xml | – fundername: NIDDK NIH HHS grantid: P30 DK098722 – fundername: NIDDK NIH HHS grantid: P30 DK092924 – fundername: NIDDK NIH HHS grantid: R01 DK124228 – fundername: NHLBI NIH HHS grantid: K24 HL112827 – fundername: ; grantid: KL2TR000143 R01AT004569 R21DK117346 2K24HL112827 |
| GroupedDBID | 53G 5VS 9T4 AAFWJ AAKDD AAYXX ACGFS ADBBV ADRAZ AFPKN ALMA_UNASSIGNED_HOLDINGS AOIJS BAWUL BCNDV CITATION DIK EMOBN GROUPED_DOAJ GX1 HYE KQ8 M48 M~E OK1 PGMZT RNS RPM ACXDI IPNFZ NPM RIG 7X8 5PM |
| ID | FETCH-LOGICAL-c465t-d00e2daa07659d50301f5e5a0bfae7997a7074afc6464de8368c57408436d77e3 |
| IEDL.DBID | DOA |
| ISICitedReferencesCount | 12 |
| ISICitedReferencesURI | http://www.webofscience.com/api/gateway?GWVersion=2&SrcApp=Summon&SrcAuth=ProQuest&DestLinkType=CitingArticles&DestApp=WOS_CPL&KeyUT=000791300800001&url=https%3A%2F%2Fcvtisr.summon.serialssolutions.com%2F%23%21%2Fsearch%3Fho%3Df%26include.ft.matches%3Dt%26l%3Dnull%26q%3D |
| ISSN | 1664-8021 |
| IngestDate | Fri Oct 03 12:49:08 EDT 2025 Thu Aug 21 18:23:04 EDT 2025 Fri Sep 05 09:16:16 EDT 2025 Thu Apr 03 07:01:01 EDT 2025 Sat Nov 29 06:21:34 EST 2025 Tue Nov 18 22:11:23 EST 2025 |
| IsDoiOpenAccess | true |
| IsOpenAccess | true |
| IsPeerReviewed | true |
| IsScholarly | true |
| Keywords | fasting blood glucose ancestry prediabetes microRNA diabetes prevention program biomarker diabetes race/ethnicity |
| Language | English |
| License | Copyright © 2022 Flowers, Kanaya, Zhang and Aouizerat. This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms. |
| LinkModel | DirectLink |
| MergedId | FETCHMERGED-LOGICAL-c465t-d00e2daa07659d50301f5e5a0bfae7997a7074afc6464de8368c57408436d77e3 |
| Notes | ObjectType-Article-1 SourceType-Scholarly Journals-1 ObjectType-Feature-2 content type line 23 Reviewed by: Mehmet Taşpinar, Aksaray University, Turkey Burak Barut, Karadeniz Technical University, Turkey Edited by: Yusuf Tutar, University of Health Sciences (Turkey), Turkey This article was submitted to RNA, a section of the journal Frontiers in Genetics |
| OpenAccessLink | https://doaj.org/article/c9411d39cd4946b7b445391d62658da3 |
| PMID | 35368704 |
| PQID | 2646946342 |
| PQPubID | 23479 |
| ParticipantIDs | doaj_primary_oai_doaj_org_article_c9411d39cd4946b7b445391d62658da3 pubmedcentral_primary_oai_pubmedcentral_nih_gov_8971619 proquest_miscellaneous_2646946342 pubmed_primary_35368704 crossref_citationtrail_10_3389_fgene_2022_853633 crossref_primary_10_3389_fgene_2022_853633 |
| PublicationCentury | 2000 |
| PublicationDate | 2022-03-18 |
| PublicationDateYYYYMMDD | 2022-03-18 |
| PublicationDate_xml | – month: 03 year: 2022 text: 2022-03-18 day: 18 |
| PublicationDecade | 2020 |
| PublicationPlace | Switzerland |
| PublicationPlace_xml | – name: Switzerland |
| PublicationTitle | Frontiers in genetics |
| PublicationTitleAlternate | Front Genet |
| PublicationYear | 2022 |
| Publisher | Frontiers Media S.A |
| Publisher_xml | – name: Frontiers Media S.A |
| References | (B18) 1999; 22 Vandesompele (B19) 2002; 3 Zhao (B21) 2016; 59 Ahlqvist (B1) 2018; 6 Herder (B10) 2021; 70 Flowers (B7) 2021; 41 Ren (B14) 2021; 12 (B17) 2000; 23 Ambros (B2) 2003; 9 Santovito (B15) 2021; 11 Zou (B22) 2019; 7 B5 Grieco (B8) 2017; 66 Flanagin (B6) 2021; 326 (B16) 2002; 25 Lozano-Bartolomé (B12) 2018; 103 Zampetaki (B20) 2010; 107 Jaeger (B11) 2018; 8 Nunez Lopez (B13) 2019; 20 Anjana (B3) 2020; 8 Borrell (B4) 2021; 384 Haw (B9) 2021; 21 |
| References_xml | – volume: 326 start-page: 621 year: 2021 ident: B6 article-title: Updated Guidance on the Reporting of Race and Ethnicity in Medical and Science Journals publication-title: JAMA doi: 10.1001/jama.2021.13304 – volume: 21 start-page: 2 year: 2021 ident: B9 article-title: Diabetes Complications in Racial and Ethnic Minority Populations in the USA publication-title: Curr. Diab Rep. doi: 10.1007/s11892-020-01369-x – volume: 11 start-page: 4136 year: 2021 ident: B15 article-title: Plasma microRNA Signature Associated with Retinopathy in Patients with Type 2 Diabetes publication-title: Sci. Rep. doi: 10.1038/s41598-021-83047-w – volume: 384 start-page: 474 year: 2021 ident: B4 article-title: Race and Genetic Ancestry in Medicine - A Time for Reckoning with Racism publication-title: N. Engl. J. Med. doi: 10.1056/nejmms2029562 – volume: 70 start-page: 1198 year: 2021 ident: B10 article-title: Differences in Biomarkers of Inflammation between Novel Subgroups of Recent-Onset Diabetes publication-title: Diabetes doi: 10.2337/db20-1054 – volume: 20 start-page: 63 year: 2019 ident: B13 article-title: Predicting and Understanding the Response to Short-Term Intensive Insulin Therapy in People with Early Type 2 Diabetes publication-title: Mol. Metab. doi: 10.1016/j.molmet.2018.11.003 – volume: 7 start-page: 9 year: 2019 ident: B22 article-title: Novel Subgroups of Patients with Adult-Onset Diabetes in Chinese and US Populations publication-title: Lancet Diabetes Endocrinol. doi: 10.1016/s2213-8587(18)30316-4 – volume: 22 start-page: 623 year: 1999 ident: B18 article-title: The Diabetes Prevention Program. Design and Methods for a Clinical Trial in the Prevention of Type 2 Diabetes publication-title: Diabetes Care doi: 10.2337/diacare.22.4.623 – volume: 25 start-page: 2165 year: 2002 ident: B16 article-title: The Diabetes Prevention Program (DPP): Description of Lifestyle Intervention publication-title: Diabetes Care doi: 10.2337/diacare.25.12.2165 – volume: 8 start-page: e001506 year: 2020 ident: B3 article-title: Novel Subgroups of Type 2 Diabetes and Their Association with Microvascular Outcomes in an Asian Indian Population: a Data-Driven Cluster Analysis: the INSPIRED Study publication-title: BMJ Open Diabetes Res. Care doi: 10.1136/bmjdrc-2020-001506 – volume: 23 start-page: 1619 year: 2000 ident: B17 article-title: The Diabetes Prevention Program: Baseline Characteristics of the Randomized Cohort. The Diabetes Prevention Program Research Group publication-title: Diabetes Care doi: 10.2337/diacare.23.11.1619 – ident: B5 – volume: 9 start-page: 277 year: 2003 ident: B2 article-title: A Uniform System for microRNA Annotation publication-title: RNA doi: 10.1261/rna.2183803 – volume: 41 start-page: 570 year: 2021 ident: B7 article-title: Circulating microRNAs Associated with Prediabetes and Geographic Location in Latinos publication-title: Int. J. Diabetes Dev. Ctries doi: 10.1007/s13410-020-00917-1 – volume: 59 start-page: 644 year: 2016 ident: B21 article-title: miR-23b-3p Induces the Cellular Metabolic Memory of High Glucose in Diabetic Retinopathy through a SIRT1-dependent Signalling Pathway publication-title: Diabetologia doi: 10.1007/s00125-015-3832-0 – volume: 66 start-page: 100 year: 2017 ident: B8 article-title: MicroRNAs miR-23a-3p, miR-23b-3p, and miR-149-5p Regulate the Expression of Proapoptotic BH3-Only Proteins DP5 and PUMA in Human Pancreatic β-Cells publication-title: Diabetes doi: 10.2337/db16-0592 – volume: 12 start-page: 614068 year: 2021 ident: B14 article-title: Emerging Role of MiR-192-5p in Human Diseases publication-title: Front. Pharmacol. doi: 10.3389/fphar.2021.614068 – volume: 8 start-page: 14274 year: 2018 ident: B11 article-title: Circulating microRNAs -192 and -194 Are Associated with the Presence and Incidence of Diabetes Mellitus publication-title: Sci. Rep. doi: 10.1038/s41598-018-32274-9 – volume: 3 start-page: RESEARCH0034 year: 2002 ident: B19 article-title: Accurate Normalization of Real-Time Quantitative RT-PCR Data by Geometric Averaging of Multiple Internal Control Genes publication-title: Genome Biol. doi: 10.1186/gb-2002-3-7-research0034 – volume: 103 start-page: 1447 year: 2018 ident: B12 article-title: Altered Expression of miR-181a-5p and miR-23a-3p Is Associated with Obesity and TNFα-Induced Insulin Resistance publication-title: J. Clin. Endocrinol. Metab. doi: 10.1210/jc.2017-01909 – volume: 107 start-page: 810 year: 2010 ident: B20 article-title: Plasma microRNA Profiling Reveals Loss of Endothelial miR-126 and Other microRNAs in Type 2 Diabetes publication-title: Circ. Res. doi: 10.1161/circresaha.110.226357 – volume: 6 start-page: 361 year: 2018 ident: B1 article-title: Novel Subgroups of Adult-Onset Diabetes and Their Association with Outcomes: a Data-Driven Cluster Analysis of Six Variables publication-title: Lancet Diabetes Endocrinol. doi: 10.1016/s2213-8587(18)30051-2 |
| SSID | ssj0000493334 |
| Score | 2.3475325 |
| Snippet | Prior studies focused on circulating microRNAs and the risk for complex diseases have shown inconsistent findings. The majority of studies focused on European... |
| SourceID | doaj pubmedcentral proquest pubmed crossref |
| SourceType | Open Website Open Access Repository Aggregation Database Index Database Enrichment Source |
| StartPage | 853633 |
| SubjectTerms | biomarker diabetes fasting blood glucose Genetics microRNA prediabetes race/ethnicity |
| Title | The Role of Racial and Ethnic Factors in MicroRNA Expression and Risk for Type 2 Diabetes |
| URI | https://www.ncbi.nlm.nih.gov/pubmed/35368704 https://www.proquest.com/docview/2646946342 https://pubmed.ncbi.nlm.nih.gov/PMC8971619 https://doaj.org/article/c9411d39cd4946b7b445391d62658da3 |
| Volume | 13 |
| WOSCitedRecordID | wos000791300800001&url=https%3A%2F%2Fcvtisr.summon.serialssolutions.com%2F%23%21%2Fsearch%3Fho%3Df%26include.ft.matches%3Dt%26l%3Dnull%26q%3D |
| hasFullText | 1 |
| inHoldings | 1 |
| isFullTextHit | |
| isPrint | |
| journalDatabaseRights | – providerCode: PRVAON databaseName: DOAJ Directory of Open Access Journals customDbUrl: eissn: 1664-8021 dateEnd: 99991231 omitProxy: false ssIdentifier: ssj0000493334 issn: 1664-8021 databaseCode: DOA dateStart: 20100101 isFulltext: true titleUrlDefault: https://www.doaj.org/ providerName: Directory of Open Access Journals – providerCode: PRVHPJ databaseName: ROAD: Directory of Open Access Scholarly Resources customDbUrl: eissn: 1664-8021 dateEnd: 99991231 omitProxy: false ssIdentifier: ssj0000493334 issn: 1664-8021 databaseCode: M~E dateStart: 20100101 isFulltext: true titleUrlDefault: https://road.issn.org providerName: ISSN International Centre |
| link | http://cvtisr.summon.serialssolutions.com/2.0.0/link/0/eLvHCXMwrV1Li9RAEC50UfAivh0fSwuehLhJ-n1cZQYvO8igMJ6aTj_Y6NIjO7PLevG3W53ODjMievGSQ9KdVKoqqa-6i68AXreNiK7WttJUY4Iia18p51hlO8d8kBFjcGk2IedztVzqjzutvnJNWKEHLoo7cpo1jafaeaaZ6GTHGMfbegTiXHk78Hwi6tlJpr4W3EspZWUbE7MwfRTRHpkWs23fYoQSlO4FooGv_08g8_dayZ3gM7sHd0fUSI6LtPfhRkgP4HbpI_njIXxBY5PF6iyQVSQLm1fBiU2eTDenqXdkVnrqkD6Rk1x_t5gfk-nVWAGbhpGLfv2NIH4lOS8lLRkLZdaP4PNs-un9h2rsmVA5Jvim8nUdWm9tLQXXnueEJ_LAbd1FG6TW0koEDTY6wQQaQ1GhHJesVowKL2Wgj-EgrVJ4CkSLDt2MKyGjYlbRznY2hOiF9DGqyCZQXyvQuJFQPPe1ODOYWGSdm0HnJuvcFJ1P4M12yvfCpvG3we-yVbYDMxH2cALdw4zuYf7lHhN4dW1Tgx9O3g2xKawu1ga9UOAUytoJPCk23j6KogD4I8NXlHvW35Nl_0rqTwdybpU5uRr97H8I_xzuZH3kkrdGvYCDzflFeAm33OWmX58fwk25VIeD3-Px5Of0F6oqBlI |
| linkProvider | Directory of Open Access Journals |
| openUrl | ctx_ver=Z39.88-2004&ctx_enc=info%3Aofi%2Fenc%3AUTF-8&rfr_id=info%3Asid%2Fsummon.serialssolutions.com&rft_val_fmt=info%3Aofi%2Ffmt%3Akev%3Amtx%3Ajournal&rft.genre=article&rft.atitle=The+Role+of+Racial+and+Ethnic+Factors+in+MicroRNA+Expression+and+Risk+for+Type+2+Diabetes&rft.jtitle=Frontiers+in+genetics&rft.au=Flowers%2C+Elena&rft.au=Kanaya%2C+Alka+M.&rft.au=Zhang%2C+Li&rft.au=Aouizerat%2C+Bradley+E.&rft.date=2022-03-18&rft.issn=1664-8021&rft.eissn=1664-8021&rft.volume=13&rft_id=info:doi/10.3389%2Ffgene.2022.853633&rft.externalDBID=n%2Fa&rft.externalDocID=10_3389_fgene_2022_853633 |
| thumbnail_l | http://covers-cdn.summon.serialssolutions.com/index.aspx?isbn=/lc.gif&issn=1664-8021&client=summon |
| thumbnail_m | http://covers-cdn.summon.serialssolutions.com/index.aspx?isbn=/mc.gif&issn=1664-8021&client=summon |
| thumbnail_s | http://covers-cdn.summon.serialssolutions.com/index.aspx?isbn=/sc.gif&issn=1664-8021&client=summon |