Mitochondrial Reactive Oxygen Species and Their Contribution in Chronic Kidney Disease Progression Through Oxidative Stress

Mitochondria are known to generate approximately 90% of cellular reactive oxygen species (ROS). The imbalance between mitochondrial reactive oxygen species (mtROS) production and removal due to overproduction of ROS and/or decreased antioxidants defense activity results in oxidative stress (OS), whi...

Celý popis

Uloženo v:
Podrobná bibliografie
Vydáno v:Frontiers in physiology Ročník 12; s. 627837
Hlavní autoři: Tirichen, Hasna, Yaigoub, Hasnaa, Xu, Weiwei, Wu, Changxin, Li, Rongshan, Li, Yafeng
Médium: Journal Article
Jazyk:angličtina
Vydáno: Switzerland Frontiers Media S.A 23.04.2021
Témata:
chronic kidney disease
kidney
mitochondria
oxidative stress
Physiology
reactive oxygen species
kidney
chronic kidney disease
mitochondria
oxidative stress
reactive oxygen species
ISSN:1664-042X, 1664-042X
On-line přístup:Získat plný text
Tagy: Přidat tag
Žádné tagy, Buďte první, kdo vytvoří štítek k tomuto záznamu!
Popis
Shrnutí:Mitochondria are known to generate approximately 90% of cellular reactive oxygen species (ROS). The imbalance between mitochondrial reactive oxygen species (mtROS) production and removal due to overproduction of ROS and/or decreased antioxidants defense activity results in oxidative stress (OS), which leads to oxidative damage that affects several cellular components such as lipids, DNA, and proteins. Since the kidney is a highly energetic organ, it is more vulnerable to damage caused by OS and thus its contribution to the development and progression of chronic kidney disease (CKD). This article aims to review the contribution of mtROS and OS to CKD progression and kidney function deterioration.
Bibliografie:ObjectType-Article-1
SourceType-Scholarly Journals-1
ObjectType-Feature-2
ObjectType-Review-3
content type line 23
Reviewed by: Daniela Valenti, National Research Council, Italy; Claudia Lagranha, Federal University of Pernambuco, Brazil; Tingyang Zhou, The Ohio State University, United States
Edited by: Simona Martinotti, Università del Piemonte Orientale, Italy
This article was submitted to Redox Physiology, a section of the journal Frontiers in Physiology
ISSN:1664-042X
1664-042X
DOI:10.3389/fphys.2021.627837