Structural Characterization of SARS-CoV-2: Where We Are, and Where We Need to Be

Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) has rapidly spread in humans in almost every country, causing the disease COVID-19. Since the start of the COVID-19 pandemic, research efforts have been strongly directed towards obtaining a full understanding of the biology of the viral i...

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Veröffentlicht in:Frontiers in molecular biosciences Jg. 7; S. 605236
Hauptverfasser: Mariano, Giuseppina, Farthing, Rebecca J., Lale-Farjat, Shamar L. M., Bergeron, Julien R. C.
Format: Journal Article
Sprache:Englisch
Veröffentlicht: Switzerland Frontiers Media S.A 17.12.2020
Schlagworte:
coronavirus
COVID19
cryo-EM
Molecular Biosciences
SARS-CoV-2
structural biology
coronavirus
SARS-CoV-2
structural biology
COVID19
cryo-EM
ISSN:2296-889X, 2296-889X
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Zusammenfassung:Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) has rapidly spread in humans in almost every country, causing the disease COVID-19. Since the start of the COVID-19 pandemic, research efforts have been strongly directed towards obtaining a full understanding of the biology of the viral infection, in order to develop a vaccine and therapeutic approaches. In particular, structural studies have allowed to comprehend the molecular basis underlying the role of many of the SARS-CoV-2 proteins, and to make rapid progress towards treatment and preventive therapeutics. Despite the great advances that have been provided by these studies, many knowledge gaps on the biology and molecular basis of SARS-CoV-2 infection still remain. Filling these gaps will be the key to tackle this pandemic, through development of effective treatments and specific vaccination strategies.
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This article was submitted to Structural Biology, a section of the journal Frontiers in Molecular Biosciences
Reviewed by: Christian Cambillau, Aix-Marseille Université, France; Dimitrios P. Vlachakis, Agricultural University of Athens, Greece
Edited by: Yan Xiang, The University of Texas Health Science Center at San Antonio, United States
ISSN:2296-889X
2296-889X
DOI:10.3389/fmolb.2020.605236