New Insights Into the Role of Autoreactive CD8 T Cells and Cytokines in Human Type 1 Diabetes

Since the establishment of the network for pancreatic organ donors with diabetes (nPOD), we have gained unprecedented insight into the pathology of human type 1 diabetes. Many of the pre-existing “dogmas”, mostly derived from studies of animal models and sometimes limited human samples, have to be r...

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Vydané v:Frontiers in endocrinology (Lausanne) Ročník 11; s. 606434
Hlavní autori: Bender, Christine, Rajendran, Sakthi, von Herrath, Matthias G.
Médium: Journal Article
Jazyk:English
Vydavateľské údaje: Switzerland Frontiers Media S.A 05.01.2021
Predmet:
autoreactive CD8 T cells
beta cells
cytokines
Endocrinology
human pancreas
type 1 diabetes
type 1 diabetes
cytokines
autoreactive CD8 T cells
beta cells
human pancreas
ISSN:1664-2392, 1664-2392
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Shrnutí:Since the establishment of the network for pancreatic organ donors with diabetes (nPOD), we have gained unprecedented insight into the pathology of human type 1 diabetes. Many of the pre-existing “dogmas”, mostly derived from studies of animal models and sometimes limited human samples, have to be revised now. For example, we have learned that autoreactive CD8 T cells are present even in healthy individuals within the exocrine pancreas. Furthermore, their “attraction” to islets probably relies on beta-cell intrinsic events, such as the over-expression of MHC class I and resulting presentation of autoantigens such as (prepro)insulin. In addition, we are discovering other signs of beta-cell dysfunction, possibly at least in part due to stress, such as the over-expression of certain cytokines. This review summarizes the latest developments focusing on cytokines and autoreactive CD8 T cells in human type 1 diabetes pathogenesis.
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Edited by: Todd M. Brusko, University of Florida, United States
Reviewed by: Guido Sebastiani, University of Siena, Italy; Eddie A. James, Benaroya Research Institute, United States; Francesco Dotta, University of Siena, Italy; Stuart Ian Mannering, University of Melbourne, Australia
Present Address: Sakthi Rajendran, Nationwide Children’s Hospital, Columbus, United States
These authors have contributed equally to this work
This article was submitted to Diabetes: Molecular Mechanisms, a section of the journal Frontiers in Endocrinology
ISSN:1664-2392
1664-2392
DOI:10.3389/fendo.2020.606434